DIABLO Antibody
Produktgrößen
100 ug
£474,00
OAED00018-100UG
Über dieses Produkt
- SKU:
- OAED00018
- Zusätzliche Namen:
- DFNA64;diablo homolog; mitochondrial;diablo-like protein;direct IAP-binding protein with low pI;second mitochondria-derived activator of caspase;SMAC.
- translate.label.attr.clone:
- 79-1-83
- Klonalität:
- Monoclonal
- Weitere Details:
- Promotes apoptosis by activating caspases in the cytochrome c/Apaf-1/caspase-9 pathway. Acts by opposing the inhibitory activity of inhibitor of apoptosis proteins (IAP). Inhibits the activity of BIRC6/bruce by inhibiting its binding to caspases. Isoform 3 attenuates the stability and apoptosis-inhibiting activity of XIAP/BIRC4 by promoting XIAP/BIRC4 ubiquitination and degradation through the ubiquitin-proteasome pathway. Isoform 3 also disrupts XIAP/BIRC4 interacting with processed caspase-9 and promotes caspase-3 activation. Isoform 1 is defective in the capacity to down-regulate the XIAP/BIRC4 abundance.
- Gendetails:
- diablo IAP-binding mitochondrial protein
- Host:
- Mouse
- Immunogen:
- Recombinant full length human Smac/DIABLO.
- Isotyp:
- IgG2b
- Proteindetails:
- Diablo homolog; mitochondrial
- Reinheit:
- Protein G affinity purified.<br/>
- Versandbedingungen:
- Blue Ice
- Lagerbedingungen:
- Long Term Storage : -20C
- Hersteller:
- Aviva Systems Biology
- Typ:
- Antibodies: Monoclonal Antibody
- Datenblatt des Herstellers:html_datasheet.php