GDF6 Antibody
Produktgrößen
100ul
£344,00
OACD03815-100UL
1ml
£955,00
OACD03815-1ML
Über dieses Produkt
- SKU:
- OACD03815
- Zusätzliche Namen:
- BMP1;BMP13;BMP-13;bone morphogenetic protein 13;GDF16;GDF-6;growth/differentiation factor 16;growth/differentiation factor 6.
- Klonalität:
- Polyclonal
- Konzentration:
- 0.5 mg/ml
- Weitere Details:
- Growth factor that controls proliferation and cellular differentiation in the retina and bone formation. Plays a key role in regulating apoptosis during retinal development. Establishes dorsal-ventral positional information in the retina and controls the formation of the retinotectal map (PubMed:23307924). Required for normal formation of bones and joints in the limbs; skull; digits and axial skeleton. Plays a key role in establishing boundaries between skeletal elements during development. Regulation of GDF6 expression seems to be a mechanism for evolving species-specific changes in skeletal strucutres (PubMed:26774823). Seems to positively regulates differentiation of chondrogenic tissue through the growth factor receptors subunits BMPR1A; BMPR1B; BMPR2 and ACVR2A; leading to the activation of SMAD1-SMAD5-SMAD8 complex. The regulation of chondrogenic differentiation is inhibited by NOG (PubMed:12606286; PubMed:16049014). Also involved in the induction of adipogenesis from mesenchymal stem cells. This mechanism acts through the growth factor receptors subunits BMPR1A; BMPR2 and ACVR2A and the activation of SMAD1-SMAD5-SMAD8 complex and MAPK14/p38 (PubMed:23527555).
- Gendetails:
- growth differentiation factor 6
- Host:
- Rabbit
- Immunogen:
- Range: Ser339 - Arg454
- Isotyp:
- IgG
- Molekulargewicht:
- 51 kDa
- Proteindetails:
- Growth/differentiation factor 6
- Aufreinigung:
- Affinity Purified; Protein A Purified
- Versandbedingungen:
- Blue Ice
- Lagerbedingungen:
- 2Â[o]C to 8Â[o]C|-20Â[o]C
- Hersteller:
- Aviva Systems Biology
- Typ:
- Antibodies: Polyclonal Antibody
- Datenblatt des Herstellers:html_datasheet.php