FCGR3A Antibody
Produktgrößen
100ul
£326,00
OACD03456-100UL
1ml
£912,00
OACD03456-1ML
Über dieses Produkt
- SKU:
- OACD03456
- Zusätzliche Namen:
- 4833442P21Rik;CD16-2;Fc fragment of IgG; low affinity IIIa; receptor for (CD16); Fc fragment of IgG; low affinity III; receptor for (CD16);Fc gammaRIV;Fc receptor-like 3;Fcgam;FcgammaRIV;Fcgr;Fcgr3a;FcgRIV;Fcrl3;low affinity immunoglobulin gamma Fc region receptor III-A;low affinity immunoglobulin gamma Fc region receptor IV.
- Klonalität:
- Polyclonal
- Konzentration:
- 1 mg/ml
- Weitere Details:
- Receptor for the Fc region of immunoglobulin gamma (PubMed:16039578). Also acts as a receptor for the Fc region of immunoglobulin epsilon (PubMed:17558411; PubMed:18949059). Binds with intermediate affinity to both IgG2a and IgG2b (PubMed:16039578; PubMed:17558411; PubMed:19795417). Can bind to IgG2a and IgG2b monomers (PubMed:18949059). Does not display binding to IgG1 or IgG3 (PubMed:16039578). Mediates neutrophil activation by IgG complexes redundantly with Fcgr3 (PubMed:18097064). Plays a role in promoting bone resorption by enhancing osteoclast differentiation following binding to IgG2a (PubMed:25824719). Binds with low affinity to both the a and b allotypes of IgE (PubMed:18949059). Has also been shown to bind to IgE allotype a only but not to allotype b (PubMed:17558411). Binds aggregated IgE but not the monomeric form and bound monomeric IgG is readily displaced by IgE complexes (PubMed:18949059). Binding to IgE promotes macrophage-mediated phagocytosis; antigen presentation to T cells; production of proinflammatory cytokines and the late phase of cutaneous allergic reactions (PubMed:17558411; PubMed:18949059).
- Gendetails:
- Fc receptor; IgG; low affinity IV
- Host:
- Rabbit
- Immunogen:
- Recombinant FcgR3A (Leu5~Ile240) expressed in E.coli
- Isotyp:
- IgG
- Proteindetails:
- Low affinity immunoglobulin gamma Fc region receptor IV
- Aufreinigung:
- Affinity Purified; Protein A Purified
- Versandbedingungen:
- Blue Ice
- Lagerbedingungen:
- 2Â[o]C to 8Â[o]C|-20Â[o]C
- Hersteller:
- Aviva Systems Biology
- Typ:
- Antibodies: Polyclonal Antibody
- Datenblatt des Herstellers:html_datasheet.php