ERN1 Antibody
Produktgrößen
100ul
£333,00
OACD03286-100UL
1ml
£933,00
OACD03286-1ML
Über dieses Produkt
- SKU:
- OACD03286
- Zusätzliche Namen:
- Endoplasmic reticulum-to-nucleus signaling 1;ER to nucleus signalling 1;hIRE1p;inositol-requiring 1;inositol-requiring enzyme 1;inositol-requiring protein 1;IRE1;IRE1a;ire1-alpha;IRE1P;protein kinase/endoribonuclease;serine/threonine-protein kinase/endoribonuclease IRE1.
- Klonalität:
- Polyclonal
- Konzentration:
- 0.5 mg/ml
- Weitere Details:
- Serine/threonine-protein kinase and endoribonuclease that acts as a key sensor for the endoplasmic reticulum unfolded protein response (UPR) (PubMed:11779464; PubMed:11175748; PubMed:12637535; PubMed:9637683; PubMed:21317875). In unstressed cells; the endoplasmic reticulum luminal domain is maintained in its inactive monomeric state by binding to the endoplasmic reticulum chaperone HSPA5/BiP (PubMed:21317875). Accumulation of misfolded protein in the endoplasmic reticulum causes release of HSPA5/BiP; allowing the luminal domain to homodimerize; promoting autophosphorylation of the kinase domain and subsequent activation of the endoribonuclease activity (PubMed:21317875). The endoribonuclease activity is specific for XBP1 mRNA and excises 26 nucleotides from XBP1 mRNA (PubMed:11779464; PubMed:24508390; PubMed:21317875). The resulting spliced transcript of XBP1 encodes a transcriptional activator protein that up-regulates expression of UPR target genes (PubMed:11779464; PubMed:24508390; PubMed:21317875).
- Gendetails:
- endoplasmic reticulum to nucleus signaling 1
- Host:
- Rabbit
- Immunogen:
- Range: Phe571 - Phe832
- Isotyp:
- IgG
- Molekulargewicht:
- 7 kDa
- Proteindetails:
- Serine/threonine-protein kinase/endoribonuclease IRE1
- Aufreinigung:
- Affinity Purified; Protein A Purified
- Versandbedingungen:
- Blue Ice
- Lagerbedingungen:
- 2Â[o]C to 8Â[o]C|-20Â[o]C
- Hersteller:
- Aviva Systems Biology
- Typ:
- Antibodies: Polyclonal Antibody
- Datenblatt des Herstellers:html_datasheet.php