DKK1 Antibody
Produktgrößen
100ul
£311,00
OACD03057-100UL
1ml
£853,00
OACD03057-1ML
Über dieses Produkt
- SKU:
- OACD03057
- Zusätzliche Namen:
- dickkopf 1 homolog;dickkopf-1 like;dickkopf-like protein 1;dickkopf-related protein 1;DKK-1;SK.
- Klonalität:
- Polyclonal
- Konzentration:
- Varies by lot. See vial for concentration.
- Weitere Details:
- Antagonizes canonical Wnt signaling by inhibiting LRP5/6 interaction with Wnt and by forming a ternary complex with the transmembrane protein KREMEN that promotes internalization of LRP5/6 (PubMed:22000856). DKKs play an important role in vertebrate development; where they locally inhibit Wnt regulated processes such as antero-posterior axial patterning; limb development; somitogenesis and eye formation. In the adult; Dkks are implicated in bone formation and bone disease; cancer and Alzheimer disease (PubMed:17143291). Inhibits the pro-apoptotic function of KREMEN1 in a Wnt-independent manner; and has anti-apoptotic activity (By similarity).
- Gendetails:
- dickkopf WNT signaling pathway inhibitor 1
- Host:
- Rabbit
- Immunogen:
- Range: Leu33 - His266
- Isotyp:
- IgG
- Molekulargewicht:
- 29 kDa
- Proteindetails:
- Dickkopf-related protein 1
- Aufreinigung:
- Affinity Purified; Protein A Purified
- Versandbedingungen:
- Blue Ice
- Lagerbedingungen:
- Store at 4°C for frequent use. Aliquot and store at -20°C for 24 months. Avoid repeated freeze/thaw cycles.
- Hersteller:
- Aviva Systems Biology
- Typ:
- Antibodies: Polyclonal Antibody
- Datenblatt des Herstellers:html_datasheet.php