CDK4 Antibody
Produktgrößen
100ul
£326,00
OACD02414-100UL
1ml
£912,00
OACD02414-1ML
Über dieses Produkt
- SKU:
- OACD02414
- Zusätzliche Namen:
- cell division protein kinase 4;Crk;Crk3;cyclin-dependent kinase 4;p34<PSK-J3>/cdk4;PSK-J3;serine/threonine kinase.
- Klonalität:
- Polyclonal
- Konzentration:
- 0.5 mg/ml
- Weitere Details:
- Ser/Thr-kinase component of cyclin D-CDK4 (DC) complexes that phosphorylate and inhibit members of the retinoblastoma (RB) protein family including RB1 and regulate the cell-cycle during G(1)/S transition. Phosphorylation of RB1 allows dissociation of the transcription factor E2F from the RB/E2F complexes and the subsequent transcription of E2F target genes which are responsible for the progression through the G(1) phase. Hypophosphorylates RB1 in early G(1) phase. Cyclin D-CDK4 complexes are major integrators of various mitogenenic and antimitogenic signals. Also phosphorylates SMAD3 in a cell-cycle-dependent manner and represses its transcriptional activity. Component of the ternary complex; cyclin D/CDK4/CDKN1B; required for nuclear translocation and activity of the cyclin D-CDK4 complex (By similarity).
- Gendetails:
- cyclin-dependent kinase 4
- Host:
- Rabbit
- Immunogen:
- Range: Tyr6 - Leu295
- Isotyp:
- IgG
- Molekulargewicht:
- 34 kDa
- Proteindetails:
- Cyclin-dependent kinase 4
- Aufreinigung:
- Affinity Purified; Protein A Purified
- Versandbedingungen:
- Blue Ice
- Lagerbedingungen:
- 2Â[o]C to 8Â[o]C|-20Â[o]C
- Hersteller:
- Aviva Systems Biology
- Typ:
- Antibodies: Polyclonal Antibody
- Datenblatt des Herstellers:html_datasheet.php