CD8B Antibody
Produktgrößen
100ul
£381,00
OACD02359-100UL
1ml
£1096,00
OACD02359-1ML
Über dieses Produkt
- SKU:
- OACD02359
- Zusätzliche Namen:
- CD8 antigen 37 kDa chain;CD8 antigen beta-chain;Cd8b1;OX-8 membrane antigen;T-cell surface glycoprotein CD8 beta chain.
- Klonalität:
- Polyclonal
- Konzentration:
- 0.5 mg/ml
- Weitere Details:
- Integral membrane glycoprotein that plays an essential role in the immune response and serves multiple functions in responses against both external and internal offenses. In T-cells; functions primarily as a coreceptor for MHC class I molecule:peptide complex. The antigens presented by class I peptides are derived from cytosolic proteins while class II derived from extracellular proteins. Interacts simultaneously with the T-cell receptor (TCR) and the MHC class I proteins presented by antigen presenting cells (APCs). In turn; recruits the Src kinase LCK to the vicinity of the TCR-CD3 complex. A palmitoylation site in the cytoplasmic tail of CD8B chain contributes to partitioning of CD8 into the plasma membrane lipid rafts where signaling proteins are enriched. Once LCK recruited; it initiates different intracellular signaling pathways by phosphorylating various substrates ultimately leading to lymphokine production; motility; adhesion and activation of cytotoxic T-lymphocytes (CTLs). Additionally; plays a critical role in thymic selection of CD8+ T-cells.
- Gendetails:
- CD8b molecule
- Host:
- Rabbit
- Immunogen:
- Range: Ala21 - Lys208
- Isotyp:
- IgG
- Molekulargewicht:
- 23 kDa
- Proteindetails:
- T-cell surface glycoprotein CD8 beta chain
- Aufreinigung:
- Affinity Purified; Protein A Purified
- Versandbedingungen:
- Blue Ice
- Lagerbedingungen:
- 2Â[o]C to 8Â[o]C|-20Â[o]C
- Hersteller:
- Aviva Systems Biology
- Typ:
- Antibodies: Polyclonal Antibody
- Datenblatt des Herstellers:html_datasheet.php