CPEB1 Antibody
Produktgrößen
100ul
£333,00
OACD01185-100UL
1ml
£933,00
OACD01185-1ML
Über dieses Produkt
- SKU:
- OACD01185
- Zusätzliche Namen:
- CPEB;CPEB-1;CPE-binding protein 1;CPE-BP1;cytoplasmic polyadenylation element-binding protein 1;h-CPEB;hCPEB-1.
- Klonalität:
- Polyclonal
- Konzentration:
- 0.5 mg/ml
- Weitere Details:
- Sequence-specific RNA-binding protein that regulates mRNA cytoplasmic polyadenylation and translation initiation during oocyte maturation; early development and at postsynapse sites of neurons. Binds to the cytoplasmic polyadenylation element (CPE); an uridine-rich sequence element (consensus sequence 5'-UUUUUAU-3') within the mRNA 3'-UTR. RNA binding results in a clear conformational change analogous to the Venus fly trap mechanism (PubMed:24990967). In absence of phosphorylation and in association with TACC3 is also involved as a repressor of translation of CPE-containing mRNA; a repression that is relieved by phosphorylation or degradation (By similarity). Involved in the transport of CPE-containing mRNA to dendrites; those mRNAs may be transported to dendrites in a translationally dormant form and translationally activated at synapses (By similarity). Its interaction with APLP1 promotes local CPE-containing mRNA polyadenylation and translation activation (By similarity). Induces the assembly of stress granules in the absence of stress. Required for cell cycle progression; specifically for prophase entry (PubMed:26398195).
- Gendetails:
- cytoplasmic polyadenylation element binding protein 1
- Host:
- Rabbit
- Immunogen:
- Range: Cys311 - Ser561
- Isotyp:
- IgG
- Molekulargewicht:
- 54 kDa
- Proteindetails:
- Cytoplasmic polyadenylation element-binding protein 1
- Aufreinigung:
- Affinity Purified; Protein A Purified
- Versandbedingungen:
- Blue Ice
- Lagerbedingungen:
- 2Â[o]C to 8Â[o]C|-20Â[o]C
- Hersteller:
- Aviva Systems Biology
- Typ:
- Antibodies: Polyclonal Antibody
- Datenblatt des Herstellers:html_datasheet.php