EPRS Antibody
Produktgrößen
100ul
£333,00
OACD00671-100UL
1ml
£933,00
OACD00671-1ML
Über dieses Produkt
- SKU:
- OACD00671
- Zusätzliche Namen:
- bifunctional aminoacyl-tRNA synthetase;bifunctional glutamate/proline--tRNA ligase;cell proliferation-inducing gene 32 protein;EARS;EPRS;GLUPRORS;glutamate tRNA ligase;glutamatyl-prolyl-tRNA synthetase;glutaminyl-tRNA synthetase;HLD15;PARS;PIG32;proliferation-inducing gene 32 protein;proliferation-inducing protein 32;proline-tRNA ligase;prolyl-tRNA synthetase;QARS;QPRS.
- Klonalität:
- Polyclonal
- Konzentration:
- 0.5 mg/ml
- Weitere Details:
- Multifunctional protein which is primarily part of the aminoacyl-tRNA synthetase multienzyme complex; also know as multisynthetase complex; that catalyzes the attachment of the cognate amino acid to the corresponding tRNA in a two-step reaction: the amino acid is first activated by ATP to form a covalent intermediate with AMP and is then transferred to the acceptor end of the cognate tRNA (PubMed:1756734; PubMed:24100331; PubMed:23263184). The phosphorylation of EPRS; induced by interferon-gamma; dissociates the protein from the aminoacyl-tRNA synthetase multienzyme complex and recruits it to the GAIT complex that binds to stem loop-containing GAIT elements in the 3'-UTR of diverse inflammatory mRNAs (such as ceruplasmin); suppressing their translation. Interferon-gamma can therefore redirect; in specific cells; the EPRS function from protein synthesis to translation inhibition (PubMed:15479637; PubMed:23071094). Also functions as an effector of the mTORC1 signaling pathway by promoting; through SLC27A1; the uptake of long-chain fatty acid by adipocytes. Thereby; it also plays a role in fat metabolism and more indirectly influences lifespan (PubMed:28178239).
- Gendetails:
- glutamyl-prolyl-tRNA synthetase 1
- Host:
- Rabbit
- Immunogen:
- Range: Asp749 - Thr956
- Isotyp:
- IgG
- Molekulargewicht:
- 171 kDa
- Proteindetails:
- Bifunctional glutamate/proline--tRNA ligase
- Aufreinigung:
- Affinity Purified; Protein A Purified
- Versandbedingungen:
- Blue Ice
- Lagerbedingungen:
- 2Â[o]C to 8Â[o]C|-20Â[o]C
- Hersteller:
- Aviva Systems Biology
- Typ:
- Antibodies: Polyclonal Antibody
- Datenblatt des Herstellers:html_datasheet.php