ESRRB Antibody
Produktgrößen
100ul
£344,00
OACD00531-100UL
1ml
£955,00
OACD00531-1ML
Über dieses Produkt
- SKU:
- OACD00531
- Zusätzliche Namen:
- ER;Err2;Errb;ERR-beta;Est;estrogen receptor related 2;estrogen receptor-like 2;Estrogen-related receptor beta;Estrrb;Nr3b2;nuclear receptor subfamily 3 group B member 2;steroid hormone receptor ERR2.
- Klonalität:
- Polyclonal
- Konzentration:
- 0.5 mg/ml
- Weitere Details:
- Transcription factor that binds a canonical ESRRB recognition (ERRE) sequence 5'TCAAGGTCA-3' localized on promoter and enhancer of targets genes regulating their expression or their transcriptional activity (PubMed:27601327; PubMed:23169531; PubMed:23508100; PubMed:26206133; PubMed:20534447; PubMed:18662995; PubMed:18957414; PubMed:27723719; PubMed:23019124). Plays a role; in a LIF-independent manner; in maintainance of self-renewal and pluripotency of embryonic and trophoblast stem cells through different signaling pathways including FGF signaling pathway and Wnt signaling pathways (PubMed:18957414; PubMed:26206133; PubMed:20534447; PubMed:23040478; PubMed:23040477; PubMed:23019124; PubMed:23169531). Upon FGF signaling pathway activation; interacts with KDM1A by directly binding to enhancer site of ELF5 and EOMES and activating their transcription leading to self-renewal of trophoblast stem cells (PubMed:26206133). Also regulates expression of multiple rod-specific genes and is required for survival of this cell type (PubMed:20534447). Plays a role as transcription factor activator of GATA6; NR0B1; POU5F1 and PERM1 (PubMed:18662995; PubMed:23508100; PubMed:18957414). Plays a role as transcription factor repressor of NFE2L2 transcriptional activity and ESR1 transcriptional activity (By similarity). During mitosis remains bound to a subset of interphase target genes; including pluripotency regulators; through the canonical ESRRB recognition (ERRE) sequence; leading to their transcriptional activation in early G1 phase (PubMed:27723719). Can coassemble on structured DNA elements with other transcription factors like SOX2; POU5F1; KDM1A and NCOA3 to trigger ESRRB-dependent gene activation (PubMed:23019124; PubMed:23169531; PubMed:18662995; PubMed:26206133). This mechanism; in the case of SOX2 corecruitment prevents the embryonic stem cells (ESCs) to epiblast stem cells (EpiSC) transition through positive regulation of NR0B1 that inhibits the EpiSC transcriptional program (PubMed:23169531). Also plays a role inner ear development by controlling expression of ion channels and transporters and in early placentation (PubMed:9285590; PubMed:17765677).
- Gendetails:
- estrogen related receptor; beta
- Host:
- Rabbit
- Immunogen:
- Range: Met166 - Val438
- Isotyp:
- IgG
- Molekulargewicht:
- 48 kDa
- Proteindetails:
- Steroid hormone receptor ERR2
- Aufreinigung:
- Affinity Purified; Protein A Purified
- Versandbedingungen:
- Blue Ice
- Lagerbedingungen:
- 2Â[o]C to 8Â[o]C|-20Â[o]C
- Hersteller:
- Aviva Systems Biology
- Typ:
- Antibodies: Polyclonal Antibody
- Datenblatt des Herstellers:html_datasheet.php