ANGPT1 Antibody
Produktgrößen
100ul
£294,00
OACD00103-100UL
200ul
£376,00
OACD00103-200UL
1ml
£793,00
OACD00103-1ML
Über dieses Produkt
- SKU:
- OACD00103
- Zusätzliche Namen:
- AGP1;AGPT;ANG1;ANG-1;angiopoietin-1;HAE5.
- translate.label.attr.clone:
- C9
- Klonalität:
- Monoclonal
- Konzentration:
- 1 mg/ml
- Weitere Details:
- Binds and activates TEK/TIE2 receptor by inducing its dimerization and tyrosine phosphorylation. Plays an important role in the regulation of angiogenesis; endothelial cell survival; proliferation; migration; adhesion and cell spreading; reorganization of the actin cytoskeleton; but also maintenance of vascular quiescence. Required for normal angiogenesis and heart development during embryogenesis. After birth; activates or inhibits angiogenesis; depending on the context. Inhibits angiogenesis and promotes vascular stability in quiescent vessels; where endothelial cells have tight contacts. In quiescent vessels; ANGPT1 oligomers recruit TEK to cell-cell contacts; forming complexes with TEK molecules from adjoining cells; and this leads to preferential activation of phosphatidylinositol 3-kinase and the AKT1 signaling cascades. In migrating endothelial cells that lack cell-cell adhesions; ANGT1 recruits TEK to contacts with the extracellular matrix; leading to the formation of focal adhesion complexes; activation of PTK2/FAK and of the downstream kinases MAPK1/ERK2 and MAPK3/ERK1; and ultimately to the stimulation of sprouting angiogenesis. Mediates blood vessel maturation/stability. Implicated in endothelial developmental processes later and distinct from that of VEGF. Appears to play a crucial role in mediating reciprocal interactions between the endothelium and surrounding matrix and mesenchyme.
- Gendetails:
- angiopoietin 1
- Host:
- Mouse
- Immunogen:
- Recombinant ANGPT1 (Arg284~Cys452) expressed in E.coli
- Isotyp:
- IgG
- Proteindetails:
- Angiopoietin-1
- Aufreinigung:
- Protein A/G Purified
- Versandbedingungen:
- Blue Ice
- Lagerbedingungen:
- 2Â[o]C to 8Â[o]C|-20Â[o]C
- Hersteller:
- Aviva Systems Biology
- Typ:
- Antibodies: Monoclonal Antibody
- Datenblatt des Herstellers:html_datasheet.php