CDYL Antibody
Produktgrößen
50ug
£305,00
OACA10725-50UG
100ug
£463,00
OACA10725-100UG
Über dieses Produkt
- SKU:
- OACA10725
- Zusätzliche Namen:
- CDYL1;CDY-like; autosomal;chromodomain protein; Y-like;chromodomain Y-like protein;crotonyl-CoA hydratase;testis-specific chromodomain Y-like protein.
- Klonalität:
- Polyclonal
- Konjugat:
- Unconjugated
- Weitere Details:
- Isoform 2: Chromatin reader protein that recognizes and binds histone H3 trimethylated at 'Lys-9'; dimethylated at 'Lys-27' and trimethylated at 'Lys-27' (H3K9me3; H3K27me2 and H3K27me3; respectively) (PubMed:19808672; PubMed:28402439). Part of multimeric repressive chromatin complexes; where it is required for transmission and restoration of repressive histone marks; thereby preserving the epigenetic landscape (PubMed:28402439). Required for chromatin targeting and maximal enzymatic activity of Polycomb repressive complex 2 (PRC2); acts as a positive regulator of PRC2 activity by bridging the pre-existing histone H3K27me3 and newly recruited PRC2 on neighboring nucleosomes (PubMed:22009739). Acts as a corepressor for REST by facilitating histone-lysine N-methyltransferase EHMT2 recruitment and H3K9 dimethylation at REST target genes for repression (PubMed:19061646). Involved X chromosome inactivation in females: recruited to Xist RNA-coated X chromosome and facilitates propagation of H3K9me2 by anchoring EHMT2 (By similarity). Required for neuronal migration during brain development by repressing expression of RHOA (By similarity). In addition to act as a chromatin reader; acts as a hydro-lyase (PubMed:28803779). Shows crotonyl-coA hydratase activity by mediating the conversion of crotonyl-CoA ((2E)-butenoyl-CoA) to beta-hydroxybutyryl-CoA (3-hydroxybutanoyl-CoA); thereby acting as a negative regulator of histone crotonylation (PubMed:28803779). Histone crotonylation is required during spermatogenesis; down-regulation of histone crotonylation by CDYL regulates the reactivation of sex chromosome-linked genes in round spermatids and histone replacement in elongating spermatids (By similarity).
- Gendetails:
- chromodomain Y like
- Host:
- Rabbit
- Immunogen:
- Recombinant Human Chromodomain Y-like protein (8-260AA)
- Isotyp:
- IgG
- Proteindetails:
- Chromodomain Y-like protein
- Reinheit:
- >95%
- Aufreinigung:
- Protein G Purified
- Versandbedingungen:
- Blue Ice
- Lagerbedingungen:
- -20Â[o]C or -80Â[o]C
- Hersteller:
- Aviva Systems Biology
- Typ:
- Antibodies: Polyclonal Antibody
- Datenblatt des Herstellers:html_datasheet.php