CREB3L1 Antibody
Produktgrößen
50ug
£305,00
OACA10654-50UG
100ug
£463,00
OACA10654-100UG
Über dieses Produkt
- SKU:
- OACA10654
- Zusätzliche Namen:
- BBF-2 homolog;cAMP-responsive element-binding protein 3-like protein 1;cyclic AMP-responsive element-binding protein 3-like protein 1;OASIS;OI16;old astrocyte specifically-induced substance.
- Klonalität:
- Polyclonal
- Konjugat:
- Unconjugated
- Weitere Details:
- Transcription factor involved in unfolded protein response (UPR). Binds the DNA consensus sequence 5'-GTGXGCXGC-3' (PubMed:21767813). In the absence of endoplasmic reticulum (ER) stress; inserted into ER membranes; with N-terminal DNA-binding and transcription activation domains oriented toward the cytosolic face of the membrane. In response to ER stress; transported to the Golgi; where it is cleaved in a site-specific manner by resident proteases S1P/MBTPS1 and S2P/MBTPS2. The released N-terminal cytosolic domain is translocated to the nucleus to effect transcription of specific target genes. Plays a critical role in bone formation through the transcription of COL1A1; and possibly COL1A2; and the secretion of bone matrix proteins. Directly binds to the UPR element (UPRE)-like sequence in an osteoblast-specific COL1A1 promoter region and induces its transcription. Does not regulate COL1A1 in other tissues; such as skin (By similarity). Required to protect astrocytes from ER stress-induced cell death. In astrocytes; binds to the cAMP response element (CRE) of the BiP/HSPA5 promoter and participate in its transcriptional activation (By similarity). Required for TGFB1 to activate genes involved in the assembly of collagen extracellular matrix (PubMed:25310401).
- Gendetails:
- cAMP responsive element binding protein 3 like 1
- Host:
- Rabbit
- Immunogen:
- Recombinant Human Cyclic AMP-responsive element-binding protein 3-like protein 1 protein (396-500AA)
- Isotyp:
- IgG
- Proteindetails:
- Cyclic AMP-responsive element-binding protein 3-like protein 1
- Reinheit:
- >95%
- Aufreinigung:
- Protein G Purified
- Versandbedingungen:
- Blue Ice
- Lagerbedingungen:
- -20Â[o]C or -80Â[o]C
- Hersteller:
- Aviva Systems Biology
- Typ:
- Antibodies: Polyclonal Antibody
- Datenblatt des Herstellers:html_datasheet.php