CHD5 Antibody
Produktgrößen
50ug
£305,00
OACA10638-50UG
100ug
£463,00
OACA10638-100UG
Über dieses Produkt
- SKU:
- OACA10638
- Zusätzliche Namen:
- ATP-dependent helicase CHD5;CHD-5;chromodomain-helicase-DNA-binding protein 5.
- Klonalität:
- Polyclonal
- Konjugat:
- Unconjugated
- Weitere Details:
- Chromatin-remodeling protein that binds DNA through histones and regulates gene transcription. May specifically recognize and bind trimethylated 'Lys-27' (H3K27me3) and non-methylated 'Lys-4' of histone H3. Plays a role in the development of the nervous system by activating the expression of genes promoting neuron terminal differentiation. In parallel; it may also positively regulate the trimethylation of histone H3 at 'Lys-27' thereby specifically repressing genes that promote the differentiation into non-neuronal cell lineages. Tumor suppressor; it regulates the expression of genes involved in cell proliferation and differentiation. Downstream activated genes may include CDKN2A that positively regulates the p53/TP53 pathway; which in turn; prevents cell proliferation. In spermatogenesis; it probably regulates histone hyperacetylation and the replacement of histones by transition proteins in chromatin; a crucial step in the condensation of spermatid chromatin and the production of functional spermatozoa.
- Gendetails:
- chromodomain helicase DNA binding protein 5
- Host:
- Rabbit
- Immunogen:
- Recombinant Human Chromodomain-helicase-DNA-binding protein 5 protein (1600-1699AA)
- Isotyp:
- IgG
- Proteindetails:
- Chromodomain-helicase-DNA-binding protein 5
- Reinheit:
- >95%
- Aufreinigung:
- Protein G Purified
- Versandbedingungen:
- Blue Ice
- Lagerbedingungen:
- -20Â[o]C or -80Â[o]C
- Hersteller:
- Aviva Systems Biology
- Typ:
- Antibodies: Polyclonal Antibody
- Datenblatt des Herstellers:html_datasheet.php