FBXO9 Antibody
Produktgrößen
50ug
£305,00
OACA10119-50UG
100ug
£463,00
OACA10119-100UG
Über dieses Produkt
- SKU:
- OACA10119
- Zusätzliche Namen:
- cross-immune reaction antigen 1;dJ341E18.2;F-box only protein 9;F-box protein Fbx9;FBX9;NY-REN-57;renal carcinoma antigen NY-REN-57;VCIA1.
- Klonalität:
- Polyclonal
- Konjugat:
- Unconjugated
- Weitere Details:
- Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of TTI1 and TELO2 in a CK2-dependent manner; thereby directly regulating mTOR signaling. SCF(FBXO9) recognizes and binds mTORC1-bound TTI1 and TELO2 when they are phosphorylated by CK2 following growth factor deprivation; leading to their degradation. In contrast; the SCF(FBXO9) does not mediate ubiquitination of TTI1 and TELO2 when they are part of the mTORC2 complex. As a consequence; mTORC1 is inactivated to restrain cell growth and protein translation; while mTORC2 is activated due to the relief of feedback inhibition by mTORC1.
- Gendetails:
- F-box protein 9
- Host:
- Rabbit
- Immunogen:
- Recombinant Human F-box only protein 9 protein (13-111AA)
- Isotyp:
- IgG
- Proteindetails:
- F-box only protein 9
- Reinheit:
- >95%
- Aufreinigung:
- Protein G Purified
- Versandbedingungen:
- Blue Ice
- Lagerbedingungen:
- -20Â[o]C or -80Â[o]C
- Hersteller:
- Aviva Systems Biology
- Typ:
- Antibodies: Polyclonal Antibody
- Datenblatt des Herstellers:html_datasheet.php