FZD8 Antibody
Produktgrößen
50ug
£305,00
OACA10109-50UG
100ug
£463,00
OACA10109-100UG
Über dieses Produkt
- SKU:
- OACA10109
- Zusätzliche Namen:
- frizzled 8; seven transmembrane spanning receptor;frizzled family receptor 8;frizzled homolog 8;frizzled-8;FZ-8;hFZ8.
- Klonalität:
- Polyclonal
- Konjugat:
- Unconjugated
- Weitere Details:
- Receptor for Wnt proteins. Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalosomes. The beta-catenin canonical signaling pathway leads to the activation of disheveled proteins; inhibition of GSK-3 kinase; nuclear accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members; but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway; as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G-proteins. May be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues. Coreceptor along with RYK of Wnt proteins; such as WNT1.
- Gendetails:
- frizzled class receptor 8
- Host:
- Rabbit
- Immunogen:
- Recombinant Human Frizzled-8 protein (55-233AA)
- Isotyp:
- IgG
- Proteindetails:
- Frizzled-8
- Reinheit:
- >95%
- Aufreinigung:
- Protein G Purified
- Versandbedingungen:
- Blue Ice
- Lagerbedingungen:
- -20Â[o]C or -80Â[o]C
- Hersteller:
- Aviva Systems Biology
- Typ:
- Antibodies: Polyclonal Antibody
- Datenblatt des Herstellers:html_datasheet.php