AAK1 Antibody
Produktgrößen
50ug
£305,00
OACA10075-50UG
100ug
£463,00
OACA10075-100UG
Über dieses Produkt
- SKU:
- OACA10075
- Zusätzliche Namen:
- adaptor-associated kinase 1;AP2-associated protein kinase 1.
- Klonalität:
- Polyclonal
- Konjugat:
- Unconjugated
- Weitere Details:
- Regulates clathrin-mediated endocytosis by phosphorylating the AP2M1/mu2 subunit of the adaptor protein complex 2 (AP-2) which ensures high affinity binding of AP-2 to cargo membrane proteins during the initial stages of endocytosis. Isoform 1 and isoform 2 display similar levels of kinase activity towards AP2M1. Regulates phosphorylation of other AP-2 subunits as well as AP-2 localization and AP-2-mediated internalization of ligand complexes. Phosphorylates NUMB and regulates its cellular localization; promoting NUMB localization to endosomes. Binds to and stabilizes the activated form of NOTCH1; increases its localization in endosomes and regulates its transcriptional activity.
- Gendetails:
- AP2 associated kinase 1
- Host:
- Rabbit
- Immunogen:
- Recombinant Human AP2-associated protein kinase 1 protein (274-465AA)
- Isotyp:
- IgG
- Proteindetails:
- AP2-associated protein kinase 1
- Reinheit:
- >95%
- Aufreinigung:
- Protein G Purified
- Versandbedingungen:
- Blue Ice
- Lagerbedingungen:
- -20Â[o]C or -80Â[o]C
- Hersteller:
- Aviva Systems Biology
- Typ:
- Antibodies: Polyclonal Antibody
- Datenblatt des Herstellers:html_datasheet.php