DES Antibody
Produktgrößen
50ug
£305,00
OACA10055-50UG
100ug
£463,00
OACA10055-100UG
Über dieses Produkt
- SKU:
- OACA10055
- Zusätzliche Namen:
- cardiomyopathy; dilated 1F (autosomal dominant);CDCD3;CSM1;CSM2;desmin;epididymis secretory sperm binding protein;intermediate filament protein;LGMD1D;LGMD1E;LGMD2R.
- Klonalität:
- Polyclonal
- Konjugat:
- Unconjugated
- Weitere Details:
- Muscle-specific type III intermediate filament essential for proper muscular structure and function. Plays a crucial role in maintaining the structure of sarcomeres; inter-connecting the Z-disks and forming the myofibrils; linking them not only to the sarcolemmal cytoskeleton; but also to the nucleus and mitochondria; thus providing strength for the muscle fiber during activity (PubMed:25358400). In adult striated muscle they form a fibrous network connecting myofibrils to each other and to the plasma membrane from the periphery of the Z-line structures (PubMed:24200904; PubMed:25394388; PubMed:26724190). May act as a sarcomeric microtubule-anchoring protein: specifically associates with detyrosinated tubulin-alpha chains; leading to buckled microtubules and mechanical resistance to contraction. Contributes to the transcriptional regulation of the NKX2-5 gene in cardiac progenitor cells during a short period of cardiomyogenesis and in cardiac side population stem cells in the adult. Plays a role in maintaining an optimal conformation of nebulette (NEB) on heart muscle sarcomeres to bind and recruit cardiac alpha-actin (By similarity).
- Gendetails:
- desmin
- Host:
- Rabbit
- Immunogen:
- Recombinant Human Desmin protein (2-86AA)
- Isotyp:
- IgG
- Proteindetails:
- Desmin
- Reinheit:
- >95%
- Aufreinigung:
- Protein G Purified
- Versandbedingungen:
- Blue Ice
- Lagerbedingungen:
- -20Â[o]C or -80Â[o]C
- Hersteller:
- Aviva Systems Biology
- Typ:
- Antibodies: Polyclonal Antibody
- Datenblatt des Herstellers:html_datasheet.php