FGFR1 Antibody
Produktgrößen
50ug
£305,00
OACA10003-50UG
100ug
£463,00
OACA10003-100UG
Über dieses Produkt
- SKU:
- OACA10003
- Zusätzliche Namen:
- basic fibroblast growth factor receptor 1;BFGFR;bFGF-R-1;CD331;CEK;ECCL;FGFBR;FGFR-1;FGFR1/PLAG1 fusion;fibroblast growth factor receptor 1;FLG;FLT2;FLT-2;FMS-like tyrosine kinase 2;fms-related tyrosine kinase 2;HBGFR;heparin-binding growth factor receptor;HH2;HRTFDS;hydroxyaryl-protein kinase;KAL2;N-SAM;OGD;proto-oncogene c-Fgr.
- Klonalität:
- Polyclonal
- Konjugat:
- Unconjugated
- Weitere Details:
- Tyrosine-protein kinase that acts as cell-surface receptor for fibroblast growth factors and plays an essential role in the regulation of embryonic development; cell proliferation; differentiation and migration. Required for normal mesoderm patterning and correct axial organization during embryonic development; normal skeletogenesis and normal development of the gonadotropin-releasing hormone (GnRH) neuronal system. Phosphorylates PLCG1; FRS2; GAB1 and SHB. Ligand binding leads to the activation of several signaling cascades. Activation of PLCG1 leads to the production of the cellular signaling molecules diacylglycerol and inositol 1;4;5-trisphosphate. Phosphorylation of FRS2 triggers recruitment of GRB2; GAB1; PIK3R1 and SOS1; and mediates activation of RAS; MAPK1/ERK2; MAPK3/ERK1 and the MAP kinase signaling pathway; as well as of the AKT1 signaling pathway. Promotes phosphorylation of SHC1; STAT1 and PTPN11/SHP2. In the nucleus; enhances RPS6KA1 and CREB1 activity and contributes to the regulation of transcription. FGFR1 signaling is down-regulated by IL17RD/SEF; and by FGFR1 ubiquitination; internalization and degradation.
- Gendetails:
- fibroblast growth factor receptor 1
- Host:
- Rabbit
- Immunogen:
- Recombinant Human Fibroblast growth factor receptor 1 protein (22-96AA)
- Isotyp:
- IgG
- Proteindetails:
- Fibroblast growth factor receptor 1
- Reinheit:
- >95%
- Aufreinigung:
- Protein G Purified
- Versandbedingungen:
- Blue Ice
- Lagerbedingungen:
- -20Â[o]C or -80Â[o]C
- Hersteller:
- Aviva Systems Biology
- Typ:
- Antibodies: Polyclonal Antibody
- Datenblatt des Herstellers:html_datasheet.php