CHFR Antibody
Produktgrößen
50ug
£305,00
OACA09926-50UG
100ug
£463,00
OACA09926-100UG
Über dieses Produkt
- SKU:
- OACA09926
- Zusätzliche Namen:
- Checkpoint with forkhead and RING finger domains protein;checkpoint with forkhead and ring finger domains; E3 ubiquitin protein ligase;E3 ubiquitin-protein ligase CHFR;RING finger protein 196;RING-type E3 ubiquitin transferase CHFR;RNF116;RNF196.
- Klonalität:
- Polyclonal
- Konjugat:
- Unconjugated
- Weitere Details:
- E3 ubiquitin-protein ligase that functions in the antephase checkpoint by actively delaying passage into mitosis in response to microtubule poisons. Acts in early prophase before chromosome condensation; when the centrosome move apart from each other along the periphery of the nucleus. Probably involved in signaling the presence of mitotic stress caused by microtubule poisons by mediating the 'Lys-48'-linked ubiquitination of target proteins; leading to their degradation by the proteasome. Promotes the ubiquitination and subsequent degradation of AURKA and PLK1. Probably acts as a tumor suppressor; possibly by mediating the polyubiquitination of HDAC1; leading to its degradation. May also promote the formation of 'Lys-63'-linked polyubiquitin chains and functions with the specific ubiquitin-conjugating UBC13-MMS2 (UBE2N-UBE2V2) heterodimer. Substrates that are polyubiquitinated at 'Lys-63' are usually not targeted for degradation; but are rather involved in signaling cellular stress.
- Gendetails:
- checkpoint with forkhead and ring finger domains
- Host:
- Rabbit
- Immunogen:
- Recombinant Human E3 ubiquitin-protein ligase CHFR protein (141-422AA)
- Isotyp:
- IgG
- Proteindetails:
- E3 ubiquitin-protein ligase CHFR
- Reinheit:
- >95%
- Aufreinigung:
- Protein G Purified
- Versandbedingungen:
- Blue Ice
- Lagerbedingungen:
- -20Â[o]C or -80Â[o]C
- Hersteller:
- Aviva Systems Biology
- Typ:
- Antibodies: Polyclonal Antibody
- Datenblatt des Herstellers:html_datasheet.php