FBXW5 Antibody
Produktgrößen
50ug
£305,00
OACA09653-50UG
100ug
£463,00
OACA09653-100UG
Über dieses Produkt
- SKU:
- OACA09653
- Zusätzliche Namen:
- F-box and WD-40 domain-containing protein 5;F-box/WD repeat-containing protein 5;Fbw5;WD repeat-containing F-box protein FBW5.
- Klonalität:
- Polyclonal
- Konjugat:
- Unconjugated
- Weitere Details:
- Substrate recognition component of both SCF (SKP1-CUL1-F-box protein) and DCX (DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complexes. Substrate recognition component of the SCF(FBXW5) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of SASS6 during S phase; leading to prevent centriole reduplication. The SCF(FBXW5) complex also mediates ubiquitination and degradation of actin-regulator EPS8 during G2 phase; leading to the transient degradation of EPS8 and subsequent cell shape changes required to allow mitotic progression. Substrate-specific adapter of the DCX(FBXW5) E3 ubiquitin-protein ligase complex which mediates the polyubiquitination and subsequent degradation of TSC2. May also act as a negative regulator of MAP3K7/TAK1 signaling in the interleukin-1B (IL1B) signaling pathway.
- Gendetails:
- F-box and WD repeat domain containing 5
- Host:
- Rabbit
- Immunogen:
- Recombinant Human F-box/WD repeat-containing protein 5 protein (265-494AA)
- Isotyp:
- IgG
- Proteindetails:
- F-box/WD repeat-containing protein 5
- Reinheit:
- >95%
- Aufreinigung:
- Protein G Purified
- Versandbedingungen:
- Blue Ice
- Lagerbedingungen:
- -20Â[o]C or -80Â[o]C
- Hersteller:
- Aviva Systems Biology
- Typ:
- Antibodies: Polyclonal Antibody
- Datenblatt des Herstellers:html_datasheet.php