CENPA Antibody
Produktgrößen
50ug
£305,00
OACA09352-50UG
100ug
£463,00
OACA09352-100UG
Über dieses Produkt
- SKU:
- OACA09352
- Zusätzliche Namen:
- CenH3;CENP-A;centromere autoantigen A;Centromere protein A;centromere protein A; 17kDa;centromere-specific histone;histone H3-like centromeric protein A.
- Klonalität:
- Polyclonal
- Konjugat:
- Unconjugated
- Weitere Details:
- Histone H3-like nucleosomal protein that is specifically found in centromeric nucleosomes (PubMed:7962047; PubMed:9024683; PubMed:11756469; PubMed:14667408; PubMed:15702419; PubMed:15475964; PubMed:15282608; PubMed:17651496; PubMed:19114591; PubMed:27499292; PubMed:20739937). Replaces conventional H3 in the nucleosome core of centromeric chromatin at the inner plate of the kinetochore (PubMed:18072184). The presence of CENPA subtly modifies the nucleosome structure and the way DNA is wrapped around the nucleosome and gives rise to protruding DNA ends that are less well-ordered and rigid compared to nucleosomes containing histone H3 (PubMed:27499292; PubMed:26878239). May serve as an epigenetic mark that propagates centromere identity through replication and cell division (PubMed:15475964; PubMed:15282608; PubMed:26878239; PubMed:20739937; PubMed:21478274). Required for recruitment and assembly of kinetochore proteins; and as a consequence required for progress through mitosis; chromosome segregation and cytokinesis (PubMed:11756469; PubMed:14667408; PubMed:18072184; PubMed:23818633; PubMed:25556658; PubMed:27499292).
- Gendetails:
- centromere protein A
- Host:
- Rabbit
- Immunogen:
- Recombinant Human Histone H3-like centromeric protein A protein (1-50AA)
- Isotyp:
- IgG
- Proteindetails:
- Histone H3-like centromeric protein A
- Reinheit:
- >95%
- Aufreinigung:
- Protein G Purified
- Versandbedingungen:
- Blue Ice
- Lagerbedingungen:
- -20Â[o]C or -80Â[o]C
- Hersteller:
- Aviva Systems Biology
- Typ:
- Antibodies: Polyclonal Antibody
- Datenblatt des Herstellers:html_datasheet.php