ASPN Antibody
Produktgrößen
50ug
£305,00
OACA09339-50UG
100ug
£463,00
OACA09339-100UG
Über dieses Produkt
- SKU:
- OACA09339
- Zusätzliche Namen:
- asporin;asporin (LRR class 1);asporin proteoglycan;OS3;periodontal ligament associated protein 1;Periodontal ligament-associated protein 1;PLAP1;PLAP-1;SLRR1C;small leucine-rich protein 1C.
- Klonalität:
- Polyclonal
- Konjugat:
- Unconjugated
- Weitere Details:
- Negatively regulates periodontal ligament (PDL) differentiation and mineralization to ensure that the PDL is not ossified and to maintain homeostasis of the tooth-supporting system. Inhibits BMP2-induced cytodifferentiation of PDL cells by preventing its binding to BMPR1B/BMP type-1B receptor; resulting in inhibition of BMP-dependent activation of SMAD proteins (By similarity). Critical regulator of TGF-beta in articular cartilage and plays an essential role in cartilage homeostasis and osteoarthritis (OA) pathogenesis. Negatively regulates chondrogenesis in the articular cartilage by blocking the TGF-beta/receptor interaction on the cell surface and inhibiting the canonical TGF-beta/Smad signal. Binds calcium and plays a role in osteoblast-driven collagen biomineralization activity.
- Gendetails:
- asporin
- Host:
- Rabbit
- Immunogen:
- Recombinant Human Asporin protein (33-380AA)
- Isotyp:
- IgG
- Proteindetails:
- Asporin
- Reinheit:
- >95%
- Aufreinigung:
- Protein G Purified
- Versandbedingungen:
- Blue Ice
- Lagerbedingungen:
- -20Â[o]C or -80Â[o]C
- Hersteller:
- Aviva Systems Biology
- Typ:
- Antibodies: Polyclonal Antibody
- Datenblatt des Herstellers:html_datasheet.php