CD8B Antibody
Produktgrößen
50ul
£316,00
OACA09025-50UL
100ul
£387,00
OACA09025-100UL
Über dieses Produkt
- SKU:
- OACA09025
- Zusätzliche Namen:
- CD8 antigen; beta polypeptide 1 (p37);CD8B1;LEU2;LY3;LYT3;P37;T lymphocyte surface glycoprotein beta chain;T-cell surface glycoprotein CD8 beta chain.
- Klonalität:
- Polyclonal
- Konjugat:
- Unconjugated
- Weitere Details:
- Integral membrane glycoprotein that plays an essential role in the immune response and serves multiple functions in responses against both external and internal offenses. In T-cells; functions primarily as a coreceptor for MHC class I molecule:peptide complex. The antigens presented by class I peptides are derived from cytosolic proteins while class II derived from extracellular proteins. Interacts simultaneously with the T-cell receptor (TCR) and the MHC class I proteins presented by antigen presenting cells (APCs). In turn; recruits the Src kinase LCK to the vicinity of the TCR-CD3 complex. A palmitoylation site in the cytoplasmic tail of CD8B chain contributes to partitioning of CD8 into the plasma membrane lipid rafts where signaling proteins are enriched. Once LCK recruited; it initiates different intracellular signaling pathways by phosphorylating various substrates ultimately leading to lymphokine production; motility; adhesion and activation of cytotoxic T-lymphocytes (CTLs). Additionally; plays a critical role in thymic selection of CD8+ T-cells.
- Gendetails:
- CD8b molecule
- Host:
- Rabbit
- Immunogen:
- Recombinant Human T-cell surface glycoprotein CD8 beta chain protein (22-170AA)
- Isotyp:
- IgG
- Proteindetails:
- T-cell surface glycoprotein CD8 beta chain
- Aufreinigung:
- Affinity Purified
- Versandbedingungen:
- Blue Ice
- Lagerbedingungen:
- -20Â[o]C or -80Â[o]C
- Hersteller:
- Aviva Systems Biology
- Typ:
- Antibodies: Polyclonal Antibody
- Datenblatt des Herstellers:html_datasheet.php