CAMSAP2 Antibody
Produktgrößen
50ul
£316,00
OACA08999-50UL
100ul
£387,00
OACA08999-100UL
Über dieses Produkt
- SKU:
- OACA08999
- Zusätzliche Namen:
- calmodulin-regulated spectrin-associated protein 1-like protein 1;calmodulin-regulated spectrin-associated protein 2;CAMSAP1L1.
- Klonalität:
- Polyclonal
- Konjugat:
- Unconjugated
- Weitere Details:
- Key microtubule-organizing protein that specifically binds the minus-end of non-centrosomal microtubules and regulates their dynamics and organization (PubMed:23169647; PubMed:24486153; PubMed:24706919). Specifically recognizes growing microtubule minus-ends and autonomously decorates and stabilizes microtubule lattice formed by microtubule minus-end polymerization (PubMed:24486153; PubMed:24706919). Acts on free microtubule minus-ends that are not capped by microtubule-nucleating proteins or other factors and protects microtubule minus-ends from depolymerization (PubMed:24486153; PubMed:24706919). In addition; it also reduces the velocity of microtubule polymerization (PubMed:24486153; PubMed:24706919). Through the microtubule cytoskeleton; also regulates the organization of cellular organelles including the Golgi and the early endosomes (PubMed:27666745). Essential for the tethering; but not for nucleation of non-centrosomal microtubules at the Golgi: together with Golgi-associated proteins AKAP9 and PDE4DIP; required to tether non-centrosomal minus-end microtubules to the Golgi; an important step for polarized cell movement (PubMed:27666745). Also acts as a regulator of neuronal polarity and development: localizes to non-centrosomal microtubule minus-ends in neurons and stabilizes non-centrosomal microtubules; which is required for neuronal polarity; axon specification and dendritic branch formation (PubMed:24908486). Through the microtubule cytoskeleton; regulates the autophagosome transport (PubMed:28726242).
- Gendetails:
- calmodulin regulated spectrin associated protein family member 2
- Host:
- Rabbit
- Immunogen:
- Recombinant Human Calmodulin-regulated spectrin-associated protein 2 protein (1-150AA)
- Isotyp:
- IgG
- Proteindetails:
- Calmodulin-regulated spectrin-associated protein 2
- Aufreinigung:
- Affinity Purified
- Versandbedingungen:
- Blue Ice
- Lagerbedingungen:
- -20Â[o]C or -80Â[o]C
- Hersteller:
- Aviva Systems Biology
- Typ:
- Antibodies: Polyclonal Antibody
- Datenblatt des Herstellers:html_datasheet.php