FBXO6 Antibody
Produktgrößen
50ul
£316,00
OACA08867-50UL
100ul
£387,00
OACA08867-100UL
Über dieses Produkt
- SKU:
- OACA08867
- Zusätzliche Namen:
- FBG2;F-box only protein 6;F-box protein FBG2;F-box protein Fbx6;F-box protein that recognizes sugar chains 2;F-box/G-domain protein 2;FBS2;FBX6;Fbx6b.
- Klonalität:
- Polyclonal
- Konjugat:
- Unconjugated
- Weitere Details:
- Substrate-recognition component of some SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complexes. Involved in endoplasmic reticulum-associated degradation pathway (ERAD) for misfolded lumenal proteins by recognizing and binding sugar chains on unfolded glycoproteins that are retrotranslocated into the cytosol and promoting their ubiquitination and subsequent degradation. Able to recognize and bind denatured glycoproteins; which are modified with not only high-mannose but also complex-type oligosaccharides. Also recognizes sulfated glycans. Also involved in DNA damage response by specifically recognizing activated CHEK1 (phosphorylated on 'Ser-345'); promoting its ubiquitination and degradation. Ubiquitination of CHEK1 is required to insure that activated CHEK1 does not accumulate as cells progress through S phase; or when replication forks encounter transient impediments during normal DNA replication.
- Gendetails:
- F-box protein 6
- Host:
- Rabbit
- Immunogen:
- Recombinant Human F-box only protein 6 protein (104-293AA)
- Isotyp:
- IgG
- Proteindetails:
- F-box only protein 6
- Aufreinigung:
- Affinity Purified
- Versandbedingungen:
- Blue Ice
- Lagerbedingungen:
- -20Â[o]C or -80Â[o]C
- Hersteller:
- Aviva Systems Biology
- Typ:
- Antibodies: Polyclonal Antibody
- Datenblatt des Herstellers:html_datasheet.php