DAAM2 Antibody
Produktgrößen
50ul
£316,00
OACA08442-50UL
100ul
£387,00
OACA08442-100UL
Über dieses Produkt
- SKU:
- OACA08442
- Zusätzliche Namen:
- disheveled-associated activator of morphogenesis 2;dJ90A20A.1;NPHS24.
- Klonalität:
- Polyclonal
- Konjugat:
- Unconjugated
- Weitere Details:
- Key regulator of the Wnt signaling pathway; which is required for various processes during development; such as dorsal patterning; determination of left/right symmetry or myelination in the central nervous system. Acts downstream of Wnt ligands and upstream of beta-catenin (CTNNB1). Required for canonical Wnt signaling pathway during patterning in the dorsal spinal cord by promoting the aggregation of Disheveled (Dvl) complexes; thereby clustering and formation of Wnt receptor signalosomes and potentiating Wnt activity. During dorsal patterning of the spinal cord; inhibits oligodendrocytes differentiation via interaction with PIP5K1A. Also regulates non-canonical Wnt signaling pathway. Acts downstream of PITX2 in the developing gut and is required for left/right asymmetry within dorsal mesentery: affects mesenchymal condensation by lengthening cadherin-based junctions through WNT5A and non-canonical Wnt signaling; inducing polarized condensation in the left dorsal mesentery necessary to initiate gut rotation. Together with DAAM1; required for myocardial maturation and sarcomere assembly.
- Gendetails:
- dishevelled associated activator of morphogenesis 2
- Host:
- Rabbit
- Immunogen:
- Recombinant Human Disheveled-associated activator of morphogenesis 2 protein (1-86AA)
- Isotyp:
- IgG
- Proteindetails:
- Disheveled-associated activator of morphogenesis 2
- Aufreinigung:
- Affinity Purified
- Versandbedingungen:
- Blue Ice
- Lagerbedingungen:
- -20Â[o]C or -80Â[o]C
- Hersteller:
- Aviva Systems Biology
- Typ:
- Antibodies: Polyclonal Antibody
- Datenblatt des Herstellers:html_datasheet.php