EYA3 Antibody
Produktgrößen
50ul
£316,00
OACA08320-50UL
100ul
£387,00
OACA08320-100UL
Über dieses Produkt
- SKU:
- OACA08320
- Zusätzliche Namen:
- eyes absent 3;eyes absent homolog 3.
- Klonalität:
- Polyclonal
- Konjugat:
- Unconjugated
- Weitere Details:
- Tyrosine phosphatase that specifically dephosphorylates 'Tyr-142' of histone H2AX (H2AXY142ph). 'Tyr-142' phosphorylation of histone H2AX plays a central role in DNA repair and acts as a mark that distinguishes between apoptotic and repair responses to genotoxic stress. Promotes efficient DNA repair by dephosphorylating H2AX; promoting the recruitment of DNA repair complexes containing MDC1 (PubMed:19234442; PubMed:19351884). Its function as histone phosphatase probably explains its role in transcription regulation during organogenesis. Coactivates SIX1; and seems to coactivate SIX2; SIX4 and SIX5. The repression of precursor cell proliferation in myoblasts by SIX1 is switched to activation through recruitment of EYA3 to the SIX1-DACH1 complex and seems to be dependent on EYA3 phosphatase activity (By similarity). May be involved in development of the eye.
- Gendetails:
- EYA transcriptional coactivator and phosphatase 3
- Host:
- Rabbit
- Immunogen:
- Recombinant Human Eyes absent homolog 3 protein (1-300AA)
- Isotyp:
- IgG
- Proteindetails:
- Eyes absent homolog 3
- Aufreinigung:
- Affinity Purified
- Versandbedingungen:
- Blue Ice
- Lagerbedingungen:
- -20Â[o]C or -80Â[o]C
- Hersteller:
- Aviva Systems Biology
- Typ:
- Antibodies: Polyclonal Antibody
- Datenblatt des Herstellers:html_datasheet.php