CARD9 Antibody
Produktgrößen
50ul
£316,00
OACA07846-50UL
100ul
£387,00
OACA07846-100UL
Über dieses Produkt
- SKU:
- OACA07846
- Zusätzliche Namen:
- CANDF2;caspase recruitment domain-containing protein 9;hCARD9.
- Klonalität:
- Polyclonal
- Konjugat:
- Unconjugated
- Weitere Details:
- Adapter protein that plays a key role in innate immune response to a number of intracellular pathogens; such as C.albicans and L.monocytogenes. Is at the crossroads of ITAM-tyrosine kinase and the Toll-like receptors (TLR) and NOD2 signaling pathways. Probably controls various innate immune response pathways depending on the intracellular pathogen. In response to L.monocytogenes infection; acts by connecting NOD2 recognition of peptidoglycan to downstream activation of MAP kinases (MAPK) without activating NF-kappa-B. Also involved in activation of myeloid cells via classical ITAM-associated receptors and TLR: required for TLR-mediated activation of MAPK; while it is not required for TLR-induced activation of NF-kappa-B (By similarity). Controls CLEC7A (dectin-1)-mediated myeloid cell activation induced by the yeast cell wall component zymosan; leading to cytokine production and innate anti-fungal immunity: acts by regulating BCL10-MALT1-mediated NF-kappa-B activation pathway. Activates NF-kappa-B via BCL10. In response to the hyphal form of C.albicans; mediates CLEC6A (dectin-2)-induced I-kappa-B kinase ubiquitination; leading to NF-kappa-B activation via interaction with BCL10. In response to fungal infection; may be required for the development and subsequent differentiation of interleukin 17-producing T helper (TH-17) cells.
- Gendetails:
- caspase recruitment domain family member 9
- Host:
- Rabbit
- Immunogen:
- Recombinant Human Caspase recruitment domain-containing protein 9 protein (237-536AA)
- Isotyp:
- IgG
- Proteindetails:
- Caspase recruitment domain-containing protein 9
- Aufreinigung:
- Affinity Purified
- Versandbedingungen:
- Blue Ice
- Lagerbedingungen:
- -20Â[o]C or -80Â[o]C
- Hersteller:
- Aviva Systems Biology
- Typ:
- Antibodies: Polyclonal Antibody
- Datenblatt des Herstellers:html_datasheet.php