DCTN1 Antibody
Produktgrößen
50ul
£316,00
OACA07760-50UL
100ul
£387,00
OACA07760-100UL
Über dieses Produkt
- SKU:
- OACA07760
- Zusätzliche Namen:
- 150 kDa dynein-associated polypeptide;DAP-150;DP-150;dynactin 1 (p150; glued homolog; Drosophila);dynactin subunit 1;P135;p150-glued.
- Klonalität:
- Polyclonal
- Konjugat:
- Unconjugated
- Weitere Details:
- Plays a key role in dynein-mediated retrograde transport of vesicles and organelles along microtubules by recruiting and tethering dynein to microtubules. Binds to both dynein and microtubules providing a link between specific cargos; microtubules and dynein. Essential for targeting dynein to microtubule plus ends; recruiting dynein to membranous cargos and enhancing dynein processivity (the ability to move along a microtubule for a long distance without falling off the track). Can also act as a brake to slow the dynein motor during motility along the microtubule (PubMed:25185702). Can regulate microtubule stability by promoting microtubule formation; nucleation and polymerization and by inhibiting microtubule catastrophe in neurons. Inhibits microtubule catastrophe by binding both to microtubules and to tubulin; leading to enhanced microtubule stability along the axon (PubMed:23874158). Plays a role in metaphase spindle orientation (PubMed:22327364). Plays a role in centriole cohesion and subdistal appendage organization and function. Its recruitement to the centriole in a KIF3A-dependent manner is essential for the maintenance of centriole cohesion and the formation of subdistal appendage. Also required for microtubule anchoring at the mother centriole (PubMed:23386061). Plays a role in primary cilia formation (PubMed:25774020).
- Gendetails:
- dynactin subunit 1
- Host:
- Rabbit
- Immunogen:
- Recombinant Human Dynactin subunit 1 protein (1084-1278AA)
- Isotyp:
- IgG
- Proteindetails:
- Dynactin subunit 1
- Aufreinigung:
- Affinity Purified
- Versandbedingungen:
- Blue Ice
- Lagerbedingungen:
- -20Â[o]C or -80Â[o]C
- Hersteller:
- Aviva Systems Biology
- Typ:
- Antibodies: Polyclonal Antibody
- Datenblatt des Herstellers:html_datasheet.php