CCND3 Antibody
Produktgrößen
50ul
£316,00
OACA07751-50UL
100ul
£387,00
OACA07751-100UL
Über dieses Produkt
- SKU:
- OACA07751
- Zusätzliche Namen:
- D3-type cyclin;G1/S-specific cyclin-D3.
- Klonalität:
- Polyclonal
- Konjugat:
- Unconjugated
- Weitere Details:
- Regulatory component of the cyclin D3-CDK4 (DC) complex that phosphorylates and inhibits members of the retinoblastoma (RB) protein family including RB1 and regulates the cell-cycle during G(1)/S transition. Phosphorylation of RB1 allows dissociation of the transcription factor E2F from the RB/E2F complex and the subsequent transcription of E2F target genes which are responsible for the progression through the G(1) phase. Hypophosphorylates RB1 in early G(1) phase. Cyclin D-CDK4 complexes are major integrators of various mitogenenic and antimitogenic signals. Also substrate for SMAD3; phosphorylating SMAD3 in a cell-cycle-dependent manner and repressing its transcriptional activity. Component of the ternary complex; cyclin D3/CDK4/CDKN1B; required for nuclear translocation and activity of the cyclin D-CDK4 complex.
- Gendetails:
- cyclin D3
- Host:
- Rabbit
- Immunogen:
- Recombinant Human G1/S-specific cyclin-D3 protein (1-292AA)
- Isotyp:
- IgG
- Proteindetails:
- G1/S-specific cyclin-D3
- Aufreinigung:
- Affinity Purified
- Versandbedingungen:
- Blue Ice
- Lagerbedingungen:
- -20Â[o]C or -80Â[o]C
- Hersteller:
- Aviva Systems Biology
- Typ:
- Antibodies: Polyclonal Antibody
- Datenblatt des Herstellers:html_datasheet.php