FANCM Antibody
Produktgrößen
50ul
£316,00
OACA07731-50UL
100ul
£387,00
OACA07731-100UL
Über dieses Produkt
- SKU:
- OACA07731
- Zusätzliche Namen:
- ATP-dependent RNA helicase FANCM;FAAP250;Fanconi anemia complementation group M;Fanconi anemia group M protein;fanconi anemia-associated polypeptide of 250 kDa;KIAA1596;POF15;protein Hef ortholog;SPGF28.
- Klonalität:
- Polyclonal
- Konjugat:
- Unconjugated
- Konzentration:
- Varies by lot. See vial for exact concentration.
- Weitere Details:
- DNA-dependent ATPase component of the Fanconi anemia (FA) core complex (PubMed:16116422). Required for the normal activation of the FA pathway; leading to monoubiquitination of the FANCI-FANCD2 complex in response to DNA damage; cellular resistance to DNA cross-linking drugs; and prevention of chromosomal breakage (PubMed:16116422; PubMed:19423727; PubMed:20347428; PubMed:20347429). In complex with CENPS and CENPX; binds double-stranded DNA (dsDNA); fork-structured DNA (fsDNA) and Holliday junction substrates (PubMed:20347428; PubMed:20347429). Its ATP-dependent DNA branch migration activity can process branched DNA structures such as a movable replication fork. This activity is strongly stimulated in the presence of CENPS and CENPX (PubMed:20347429). In complex with FAAP24; efficiently binds to single-strand DNA (ssDNA); splayed-arm DNA; and 3'-flap substrates (PubMed:17289582). In vitro; on its own; strongly binds ssDNA oligomers and weakly fsDNA; but does not bind to dsDNA (PubMed:16116434).
- Gendetails:
- FA complementation group M
- Host:
- Rabbit
- Immunogen:
- Recombinant Human Fanconi anemia group M protein (390-660AA)
- Isotyp:
- IgG
- Proteindetails:
- Fanconi anemia group M protein
- Aufreinigung:
- Affinity Purified
- Versandbedingungen:
- Blue Ice
- Lagerbedingungen:
- -20Â[o]C or -80Â[o]C
- Hersteller:
- Aviva Systems Biology
- Typ:
- Antibodies: Polyclonal Antibody
- Datenblatt des Herstellers:html_datasheet.php