CLK2 Antibody
Produktgrößen
50ul
£316,00
OACA07660-50UL
100ul
£387,00
OACA07660-100UL
Über dieses Produkt
- SKU:
- OACA07660
- Zusätzliche Namen:
- CDC-like kinase 2;CLK kinase;dual specificity protein kinase CLK2.
- Klonalität:
- Polyclonal
- Konjugat:
- Unconjugated
- Weitere Details:
- Dual specificity kinase acting on both serine/threonine and tyrosine-containing substrates. Phosphorylates serine- and arginine-rich (SR) proteins of the spliceosomal complex. May be a constituent of a network of regulatory mechanisms that enable SR proteins to control RNA splicing and can cause redistribution of SR proteins from speckles to a diffuse nucleoplasmic distribution. Acts as a suppressor of hepatic gluconeogenesis and glucose output by repressing PPARGC1A transcriptional activity on gluconeogenic genes via its phosphorylation. Phosphorylates PPP2R5B thereby stimulating the assembly of PP2A phosphatase with the PPP2R5B-AKT1 complex leading to dephosphorylation of AKT1. Phosphorylates: PTPN1; SRSF1 and SRSF3. Regulates the alternative splicing of tissue factor (F3) pre-mRNA in endothelial cells.
- Gendetails:
- CDC like kinase 2
- Host:
- Rabbit
- Immunogen:
- Recombinant Human Dual specificity protein kinase CLK2 protein (240-499AA)
- Isotyp:
- IgG
- Proteindetails:
- Dual specificity protein kinase CLK2
- Aufreinigung:
- Affinity Purified
- Versandbedingungen:
- Blue Ice
- Lagerbedingungen:
- -20Â[o]C or -80Â[o]C
- Hersteller:
- Aviva Systems Biology
- Typ:
- Antibodies: Polyclonal Antibody
- Datenblatt des Herstellers:html_datasheet.php