DHX58 Antibody
Produktgrößen
50ul
£316,00
OACA07652-50UL
100ul
£387,00
OACA07652-100UL
Über dieses Produkt
- SKU:
- OACA07652
- Zusätzliche Namen:
- D11LGP2;D11lgp2e;DEXH (Asp-Glu-X-His) box polypeptide 58;LGP2;ortholog of mouse D11lgp2;probable ATP-dependent helicase LGP2;probable ATP-dependent RNA helicase DHX58;protein D11Lgp2 homolog;RIG-I-like receptor 3;RIG-I-like receptor LGP2;RLR;RLR-3;RNA helicase LGP2.
- Klonalität:
- Polyclonal
- Konjugat:
- Unconjugated
- Weitere Details:
- Acts as a regulator of DDX58/RIG-I and IFIH1/MDA5 mediated antiviral signaling. Cannot initiate antiviral signaling as it lacks the CARD domain required for activating MAVS/IPS1-dependent signaling events. Can have both negative and positive regulatory functions related to DDX58/RIG-I and IFIH1/MDA5 signaling and this role in regulating signaling may be complex and could probably depend on characteristics of the infecting virus or target cells; or both. Its inhibitory action on DDX58/RIG-I signaling may involve the following mechanisms: competition with DDX58/RIG-I for binding to the viral RNA; binding to DDX58/RIG-I and inhibiting its dimerization and interaction with MAVS/IPS1; competing with IKBKE in its binding to MAVS/IPS1 thereby inhibiting activation of interferon regulatory factor 3 (IRF3). Its positive regulatory role may involve unwinding or stripping nucleoproteins of viral RNA thereby facilitating their recognition by DDX58/RIG-I and IFIH1/MDA5. Involved in the innate immune response to various RNA viruses and some DNA viruses such as poxviruses; and also to the bacterial pathogen Listeria monocytogenes. Can bind both ssRNA and dsRNA; with a higher affinity for dsRNA. Shows a preference to 5'-triphosphorylated RNA; although it can recognize RNA lacking a 5'-triphosphate.
- Gendetails:
- DExH-box helicase 58
- Host:
- Rabbit
- Immunogen:
- Recombinant Human Probable ATP-dependent RNA helicase DHX58 protein (389-678AA)
- Isotyp:
- IgG
- Proteindetails:
- Probable ATP-dependent RNA helicase DHX58
- Aufreinigung:
- Affinity Purified
- Versandbedingungen:
- Blue Ice
- Lagerbedingungen:
- -20Â[o]C or -80Â[o]C
- Hersteller:
- Aviva Systems Biology
- Typ:
- Antibodies: Polyclonal Antibody
- Datenblatt des Herstellers:html_datasheet.php