CBLC Antibody
Produktgrößen
50ul
£316,00
OACA07388-50UL
100ul
£387,00
OACA07388-100UL
Über dieses Produkt
- SKU:
- OACA07388
- Zusätzliche Namen:
- Cas-Br-M (murine) ecotropic retroviral transforming sequence c;Cas-Br-M (murine) ectropic retroviral transforming sequence c;Cbl proto-oncogene C; E3 ubiquitin protein ligase;Cbl proto-oncogene; E3 ubiquitin protein ligase C;CBL-3;CBL-SL;E3 ubiquitin-protein ligase CBL-C;RING finger protein 57;RING-type E3 ubiquitin transferase CBL-C;RNF57;SH3-binding protein CBL-3;SH3-binding protein CBL-C;signal transduction protein CBL-C.
- Klonalität:
- Polyclonal
- Konjugat:
- Unconjugated
- Weitere Details:
- Acts as an E3 ubiquitin-protein ligase; which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes; and then transfers it to substrates promoting their degradation by the proteasome. Functionally coupled with the E2 ubiquitin-protein ligases UB2D1; UB2D2 and UB2D3. Regulator of EGFR mediated signal transduction; upon EGF activation; ubiquitinates EGFR. Isoform 1; but not isoform 2; inhibits EGF stimulated MAPK1 activation. Promotes ubiquitination of SRC phosphorylated at 'Tyr-419'. In collaboration with CD2AP may act as regulatory checkpoint for Ret signaling by modulating the rate of RET degradation after ligand activation; CD2AP converts it from an inhibitor to a promoter of RET degradation; the function limits the potency of GDNF on neuronal survival.
- Gendetails:
- Cbl proto-oncogene C
- Host:
- Rabbit
- Immunogen:
- Recombinant Human E3 ubiquitin-protein ligase CBL-C protein (245-474AA)
- Isotyp:
- IgG
- Proteindetails:
- E3 ubiquitin-protein ligase CBL-C
- Aufreinigung:
- Affinity Purified
- Versandbedingungen:
- Blue Ice
- Lagerbedingungen:
- -20Â[o]C or -80Â[o]C
- Hersteller:
- Aviva Systems Biology
- Typ:
- Antibodies: Polyclonal Antibody
- Datenblatt des Herstellers:html_datasheet.php