CD3D Antibody
Produktgrößen
50ul
£316,00
OACA07133-50UL
100ul
£387,00
OACA07133-100UL
Über dieses Produkt
- SKU:
- OACA07133
- Zusätzliche Namen:
- CD3 antigen; delta subunit;CD3 delta;CD3d antigen; delta polypeptide (TiT3 complex);CD3d molecule; delta (CD3-TCR complex);CD3-DELTA;IMD19;OKT3; delta chain;T3D;T-cell receptor T3 delta chain;T-cell surface glycoprotein CD3 delta chain.
- Klonalität:
- Polyclonal
- Konjugat:
- Unconjugated
- Weitere Details:
- Part of the TCR-CD3 complex present on T-lymphocyte cell surface that plays an essential role in adaptive immune response. When antigen presenting cells (APCs) activate T-cell receptor (TCR); TCR-mediated signals are transmitted across the cell membrane by the CD3 chains CD3D; CD3E; CD3G and CD3Z. All CD3 chains contain immunoreceptor tyrosine-based activation motifs (ITAMs) in their cytoplasmic domain. Upon TCR engagement; these motifs become phosphorylated by Src family protein tyrosine kinases LCK and FYN; resulting in the activation of downstream signaling pathways (PubMed:2470098). In addition of this role of signal transduction in T-cell activation; CD3D plays an essential role in thymocyte differentiation. Indeed; participates in correct intracellular TCR-CD3 complex assembly and surface expression. In absence of a functional TCR-CD3 complex; thymocytes are unable to differentiate properly. Interacts with CD4 and CD8 and thus serves to establish a functional link between the TCR and coreceptors CD4 and CD8; which is needed for activation and positive selection of CD4 or CD8 T-cells(PubMed:12215456).
- Gendetails:
- CD3d molecule
- Host:
- Rabbit
- Immunogen:
- Recombinant Human T-cell surface glycoprotein CD3 delta chain protein (22-105AA)
- Isotyp:
- IgG
- Proteindetails:
- T-cell surface glycoprotein CD3 delta chain
- Aufreinigung:
- Affinity Purified
- Versandbedingungen:
- Blue Ice
- Lagerbedingungen:
- -20Â[o]C or -80Â[o]C
- Hersteller:
- Aviva Systems Biology
- Typ:
- Antibodies: Polyclonal Antibody
- Datenblatt des Herstellers:html_datasheet.php