DYRK2 Antibody
Produktgrößen
50ul
£316,00
OACA06869-50UL
100ul
£387,00
OACA06869-100UL
Über dieses Produkt
- SKU:
- OACA06869
- Zusätzliche Namen:
- dual specificity tyrosine-(Y)-phosphorylation regulated kinase 2;dual specificity tyrosine-phosphorylation-regulated kinase 2.
- Klonalität:
- Polyclonal
- Konjugat:
- Unconjugated
- Weitere Details:
- Serine/threonine-protein kinase involved in the regulation of the mitotic cell cycle; cell proliferation; apoptosis; organization of the cytoskeleton and neurite outgrowth. Functions in part via its role in ubiquitin-dependent proteasomal protein degradation. Functions downstream of ATM and phosphorylates p53/TP53 at 'Ser-46'; and thereby contributes to the induction of apoptosis in response to DNA damage. Phosphorylates NFATC1; and thereby inhibits its accumulation in the nucleus and its transcription factor activity. Phosphorylates EIF2B5 at 'Ser-544'; enabling its subsequent phosphorylation and inhibition by GSK3B. Likewise; phosphorylation of NFATC1; CRMP2/DPYSL2 and CRMP4/DPYSL3 promotes their subsequent phosphorylation by GSK3B. May play a general role in the priming of GSK3 substrates. Inactivates GYS1 by phosphorylation at 'Ser-641'; and potentially also a second phosphorylation site; thus regulating glycogen synthesis. Mediates EDVP E3 ligase complex formation and is required for the phosphorylation and subsequent degradation of KATNA1. Phosphorylates TERT at 'Ser-457'; promoting TERT ubiquitination by the EDVP complex. Phosphorylates SIAH2; and thereby increases its ubiquitin ligase activity. Promotes the proteasomal degradation of MYC and JUN; and thereby regulates progress through the mitotic cell cycle and cell proliferation. Promotes proteasomal degradation of GLI2 and GLI3; and thereby plays a role in smoothened and sonic hedgehog signaling. Plays a role in cytoskeleton organization and neurite outgrowth via its phosphorylation of DCX and DPYSL2. Phosphorylates CRMP2/DPYSL2; CRMP4/DPYSL3; DCX; EIF2B5; EIF4EBP1; GLI2; GLI3; GYS1; JUN; MDM2; MYC; NFATC1; p53/TP53; TAU/MAPT and KATNA1. Can phosphorylate histone H1; histone H3 and histone H2B (in vitro). Can phosphorylate CARHSP1 (in vitro).
- Gendetails:
- dual specificity tyrosine phosphorylation regulated kinase 2
- Host:
- Rabbit
- Immunogen:
- Recombinant Human Dual specificity tyrosine-phosphorylation-regulated kinase 2 protein (502-601AA)
- Isotyp:
- IgG
- Proteindetails:
- Dual specificity tyrosine-phosphorylation-regulated kinase 2
- Aufreinigung:
- Affinity Purified
- Versandbedingungen:
- Blue Ice
- Lagerbedingungen:
- -20Â[o]C or -80Â[o]C
- Hersteller:
- Aviva Systems Biology
- Typ:
- Antibodies: Polyclonal Antibody
- Datenblatt des Herstellers:html_datasheet.php