CTCFL Antibody
Produktgrößen
50ul
£316,00
OACA06868-50UL
100ul
£387,00
OACA06868-100UL
Über dieses Produkt
- SKU:
- OACA06868
- Zusätzliche Namen:
- BORIS;BORIS-like protein;brother of the regulator of imprinted sites;cancer/testis antigen 27;CCCTC-binding factor;CT27;CTCF paralog;CTCF-like protein;CTCF-T;dJ579F20.2;HMGB1L1;transcriptional repressor CTCFL;Zinc finger protein CTCF-T.
- Klonalität:
- Polyclonal
- Konjugat:
- Unconjugated
- Weitere Details:
- Testis-specific DNA binding protein responsible for insulator function; nuclear architecture and transcriptional control; which probably acts by recruiting epigenetic chromatin modifiers. Plays a key role in gene imprinting in male germline; by participating in the establishment of differential methylation at the IGF2/H19 imprinted control region (ICR). Directly binds the unmethylated H19 ICR and recruits the PRMT7 methyltransferase; leading to methylate histone H4 'Arg-3' to form H4R3sme2. This probably leads to recruit de novo DNA methyltransferases at these sites (By similarity). Seems to act as tumor suppressor. In association with DNMT1 and DNMT3B; involved in activation of BAG1 gene expression by binding to its promoter. Required for dimethylation of H3 lysine 4 (H3K4me2) of MYC and BRCA1 promoters.
- Gendetails:
- CCCTC-binding factor like
- Host:
- Rabbit
- Immunogen:
- Recombinant Human Transcriptional repressor CTCFL protein (1-270AA)
- Isotyp:
- IgG
- Proteindetails:
- Transcriptional repressor CTCFL
- Aufreinigung:
- Affinity Purified
- Versandbedingungen:
- Blue Ice
- Lagerbedingungen:
- -20Â[o]C or -80Â[o]C
- Hersteller:
- Aviva Systems Biology
- Typ:
- Antibodies: Polyclonal Antibody
- Datenblatt des Herstellers:html_datasheet.php