EGLN1 Antibody
Produktgrößen
50ul
£316,00
OACA06859-50UL
100ul
£387,00
OACA06859-100UL
Über dieses Produkt
- SKU:
- OACA06859
- Zusätzliche Namen:
- C1orf12;ECYT3;egl nine homolog 1;egl nine-like protein 1;HALAH;HIFPH2;HIF-PH2;HIF-prolyl hydroxylase 2;HPH2;HPH-2;hypoxia-inducible factor prolyl hydroxylase 2;PHD2;prolyl hydroxylase domain-containing protein 2;SM20;SM-20;zinc finger MYND domain-containing protein 6;ZMYND6.
- Klonalität:
- Polyclonal
- Konjugat:
- Unconjugated
- Weitere Details:
- Cellular oxygen sensor that catalyzes; under normoxic conditions; the post-translational formation of 4-hydroxyproline in hypoxia-inducible factor (HIF) alpha proteins. Hydroxylates a specific proline found in each of the oxygen-dependent degradation (ODD) domains (N-terminal; NODD; and C-terminal; CODD) of HIF1A. Also hydroxylates HIF2A. Has a preference for the CODD site for both HIF1A and HIF1B. Hydroxylated HIFs are then targeted for proteasomal degradation via the von Hippel-Lindau ubiquitination complex. Under hypoxic conditions; the hydroxylation reaction is attenuated allowing HIFs to escape degradation resulting in their translocation to the nucleus; heterodimerization with HIF1B; and increased expression of hypoxy-inducible genes. EGLN1 is the most important isozyme under normoxia and; through regulating the stability of HIF1; involved in various hypoxia-influenced processes such as angiogenesis in retinal and cardiac functionality. Target proteins are preferentially recognized via a LXXLAP motif.
- Gendetails:
- egl-9 family hypoxia inducible factor 1
- Host:
- Rabbit
- Immunogen:
- Recombinant Human Egl nine homolog 1 protein (301-426AA)
- Isotyp:
- IgG
- Proteindetails:
- Egl nine homolog 1
- Aufreinigung:
- Affinity Purified
- Versandbedingungen:
- Blue Ice
- Lagerbedingungen:
- -20Â[o]C or -80Â[o]C
- Hersteller:
- Aviva Systems Biology
- Typ:
- Antibodies: Polyclonal Antibody
- Datenblatt des Herstellers:html_datasheet.php