CASP14 Antibody
Produktgrößen
50ul
£316,00
OACA06824-50UL
100ul
£387,00
OACA06824-100UL
Über dieses Produkt
- SKU:
- OACA06824
- Zusätzliche Namen:
- apoptosis-related cysteine protease;ARCI12;CASP-14;caspase 14; apoptosis-related cysteine peptidase;caspase 14; apoptosis-related cysteine protease;caspase-14.
- Klonalität:
- Polyclonal
- Konjugat:
- Unconjugated
- Weitere Details:
- Non-apoptotic caspase involved in epidermal differentiation. Is the predominant caspase in epidermal stratum corneum (PubMed:15556625). Seems to play a role in keratinocyte differentiation and is required for cornification. Regulates maturation of the epidermis by proteolytically processing filaggrin (By similarity). In vitro has a preference for the substrate [WY]-X-X-D motif and is active on the synthetic caspase substrate WEHD-ACF (PubMed:16854378; PubMed:19960512). Involved in processing of prosaposin in the epidermis (By similarity). May be involved in retinal pigment epithelium cell barrier function (PubMed:25121097). Involved in DNA degradation in differentiated keratinocytes probably by cleaving DFFA/ICAD leading to liberation of DFFB/CAD (PubMed:24743736).
- Gendetails:
- caspase 14
- Host:
- Rabbit
- Immunogen:
- Recombinant Human Caspase-14 protein (1-242AA)
- Isotyp:
- IgG
- Proteindetails:
- Caspase-14
- Aufreinigung:
- Affinity Purified
- Versandbedingungen:
- Blue Ice
- Lagerbedingungen:
- -20Â[o]C or -80Â[o]C
- Hersteller:
- Aviva Systems Biology
- Typ:
- Antibodies: Polyclonal Antibody
- Datenblatt des Herstellers:html_datasheet.php