CARD8 Antibody
Produktgrößen
50ul
£316,00
OACA06721-50UL
100ul
£387,00
OACA06721-100UL
Über dieses Produkt
- SKU:
- OACA06721
- Zusätzliche Namen:
- apoptotic protein NDPP1;CARD inhibitor of NF-kappaB-activating ligands;CARDINAL;CARD-inhibitor of NF-kappa-B-activating ligand;caspase recruitment domain-containing protein 8;DACAR;DAKAR;NDPP;NDPP1;TUCAN;tumor up-regulated CARD-containing antagonist of CASP9;tumor up-regulated CARD-containing antagonist of caspase nine.
- Klonalität:
- Polyclonal
- Konjugat:
- Unconjugated
- Weitere Details:
- Inflammasome sensor; which mediates inflammasome activation in response to various pathogen-associated signals; leading to subsequent pyroptosis of CD4(+) T-cells and macrophages (PubMed:11821383; PubMed:11408476; PubMed:15030775; PubMed:32840892; PubMed:32051255; PubMed:33542150; PubMed:34019797). Inflammasomes are supramolecular complexes that assemble in the cytosol in response to pathogens and other damage-associated signals and play critical roles in innate immunity and inflammation (PubMed:11821383; PubMed:11408476; PubMed:15030775). Acts as a recognition receptor (PRR): recognizes specific pathogens and other damage-associated signals; such as HIV-1 protease activity or Val-boroPro inhibitor; and mediates CARD8 inflammasome activation (PubMed:32840892; PubMed:33542150). In response to pathogen-associated signals; the N-terminal part of CARD8 is degraded by the proteasome; releasing the cleaved C-terminal part of the protein (Caspase recruitment domain-containing protein 8; C-terminus); which polymerizes to initiate the formation of the inflammasome complex: the CARD8 inflammasome directly recruits pro-caspase-1 (proCASP1) independently of PYCARD/ASC and promotes caspase-1 (CASP1) activation; which subsequently cleaves and activates inflammatory cytokines IL1B and IL18 and gasdermin-D (GSDMD); leading to pyroptosis (PubMed:33053349; PubMed:32840892; PubMed:32051255; PubMed:33542150). Ability to sense HIV-1 protease activity leads to the clearance of latent HIV-1 in patient CD4(+) T-cells after viral reactivation; in contrast; HIV-1 can evade CARD8-sensing when its protease remains inactive in infected cells prior to viral budding (PubMed:33542150). Also acts as a negative regulator of the NLRP3 inflammasome (PubMed:24517500). May also act as an inhibitor of NF-kappa-B activation (PubMed:11551959; PubMed:12067710).
- Gendetails:
- caspase recruitment domain family member 8
- Host:
- Rabbit
- Immunogen:
- Recombinant Human Caspase recruitment domain-containing protein 8 protein (1-200AA)
- Isotyp:
- IgG
- Proteindetails:
- Caspase recruitment domain-containing protein 8
- Aufreinigung:
- Affinity Purified
- Versandbedingungen:
- Blue Ice
- Lagerbedingungen:
- -20Â[o]C or -80Â[o]C
- Hersteller:
- Aviva Systems Biology
- Typ:
- Antibodies: Polyclonal Antibody
- Datenblatt des Herstellers:html_datasheet.php