CBFB Antibody
Produktgrößen
50ul
£316,00
OACA06678-50UL
100ul
£387,00
OACA06678-100UL
Über dieses Produkt
- SKU:
- OACA06678
- Zusätzliche Namen:
- CBF-beta;core-binding factor beta subunit;core-binding factor subunit beta;PEA2-beta;PEBP2B;PEBP2-beta;polyomavirus enhancer binding protein 2; beta subunit;Polyomavirus enhancer-binding protein 2 beta subunit;SL3/AKV core-binding factor beta subunit;SL3-3 enhancer factor 1 beta subunit;SL3-3 enhancer factor 1 subunit beta.
- Klonalität:
- Polyclonal
- Konjugat:
- Unconjugated
- Weitere Details:
- Forms the heterodimeric complex core-binding factor (CBF) with RUNX family proteins (RUNX1; RUNX2; and RUNX3). RUNX members modulate the transcription of their target genes through recognizing the core consensus binding sequence 5'-TGTGGT-3'; or very rarely; 5'-TGCGGT-3'; within their regulatory regions via their runt domain; while CBFB is a non-DNA-binding regulatory subunit that allosterically enhances the sequence-specific DNA-binding capacity of RUNX. The heterodimers bind to the core site of a number of enhancers and promoters; including murine leukemia virus; polyomavirus enhancer; T-cell receptor enhancers; LCK; IL3 and GM-CSF promoters. CBF complexes repress ZBTB7B transcription factor during cytotoxic (CD8+) T cell development. They bind to RUNX-binding sequence within the ZBTB7B locus acting as transcriptional silencer and allowing for cytotoxic T cell differentiation.
- Gendetails:
- core-binding factor subunit beta
- Host:
- Rabbit
- Immunogen:
- Recombinant Human Core-binding factor subunit beta protein (1-182AA)
- Isotyp:
- IgG
- Proteindetails:
- Core-binding factor subunit beta
- Aufreinigung:
- Affinity Purified
- Versandbedingungen:
- Blue Ice
- Lagerbedingungen:
- -20Â[o]C or -80Â[o]C
- Hersteller:
- Aviva Systems Biology
- Typ:
- Antibodies: Polyclonal Antibody
- Datenblatt des Herstellers:html_datasheet.php