GOLGA2 Antibody
Produktgrößen
50ul
£316,00
OACA06658-50UL
100ul
£387,00
OACA06658-100UL
Über dieses Produkt
- SKU:
- OACA06658
- Zusätzliche Namen:
- 130 kDa cis-Golgi matrix protein;GM130;GM130 autoantigen;golgi autoantigen; golgin subfamily a; 2;Golgi matrix protein GM130;golgin subfamily A member 2;golgin-95;SY11 protein.
- Klonalität:
- Polyclonal
- Konjugat:
- Unconjugated
- Weitere Details:
- Peripheral membrane component of the cis-Golgi stack that acts as a membrane skeleton that maintains the structure of the Golgi apparatus; and as a vesicle thether that facilitates vesicle fusion to the Golgi membrane. Together with p115/USO1 and STX5; involved in vesicle tethering and fusion at the cis-Golgi membrane to maintain the stacked and inter-connected structure of the Golgi apparatus. Plays a central role in mitotic Golgi disassembly: phosphorylation at Ser-37 by CDK1 at the onset of mitosis inhibits the interaction with p115/USO1; preventing tethering of COPI vesicles and thereby inhibiting transport through the Golgi apparatus during mitosis (By similarity). Also plays a key role in spindle pole assembly and centrosome organization (PubMed:26165940). Promotes the mitotic spindle pole assembly by activating the spindle assembly factor TPX2 to nucleate microtubules around the Golgi and capture them to couple mitotic membranes to the spindle: upon phosphorylation at the onset of mitosis; GOLGA2 interacts with importin-alpha via the nuclear localization signal region; leading to recruit importin-alpha to the Golgi membranes and liberate the spindle assembly factor TPX2 from importin-alpha. TPX2 then activates AURKA kinase and stimulates local microtubule nucleation. Upon filament assembly; nascent microtubules are further captured by GOLGA2; thus linking Golgi membranes to the spindle (PubMed:19242490; PubMed:26165940). Regulates the meiotic spindle pole assembly; probably via the same mechanism (By similarity). Also regulates the centrosome organization (PubMed:18045989; PubMed:19109421). Also required for the Golgi ribbon formation and glycosylation of membrane and secretory proteins (PubMed:16489344; PubMed:17314401).
- Gendetails:
- golgin A2
- Host:
- Rabbit
- Immunogen:
- Recombinant Human Golgin subfamily A member 2 protein (20-300AA)
- Isotyp:
- IgG
- Proteindetails:
- Golgin subfamily A member 2
- Aufreinigung:
- Affinity Purified
- Versandbedingungen:
- Blue Ice
- Lagerbedingungen:
- -20Â[o]C or -80Â[o]C
- Hersteller:
- Aviva Systems Biology
- Typ:
- Antibodies: Polyclonal Antibody
- Datenblatt des Herstellers:html_datasheet.php