EPM2A Antibody
Produktgrößen
50ul
£316,00
OACA06603-50UL
100ul
£387,00
OACA06603-100UL
Über dieses Produkt
- SKU:
- OACA06603
- Zusätzliche Namen:
- epilepsy; progressive myoclonus type 2; Lafora disease (laforin);epilepsy; progressive myoclonus type 2A; Lafora disease (laforin);EPM2;EPM2A; laforin glucan phosphatase;glucan phosphatase;glycogen phosphatase;lafora PTPase;laforin;LAFPTPase;MELF.
- Klonalität:
- Polyclonal
- Konjugat:
- Unconjugated
- Weitere Details:
- Plays an important role in preventing glycogen hyperphosphorylation and the formation of insoluble aggregates; via its activity as glycogen phosphatase; and by promoting the ubiquitination of proteins involved in glycogen metabolism via its interaction with the E3 ubiquitin ligase NHLRC1/malin. Shows strong phosphatase activity towards complex carbohydrates in vitro; avoiding glycogen hyperphosphorylation which is associated with reduced branching and formation of insoluble aggregates (PubMed:16901901; PubMed:23922729; PubMed:26231210; PubMed:25538239; PubMed:25544560). Dephosphorylates phosphotyrosine and synthetic substrates; such as para-nitrophenylphosphate (pNPP); and has low activity with phosphoserine and phosphothreonine substrates (in vitro) (PubMed:11001928; PubMed:11220751; PubMed:11739371; PubMed:14532330; PubMed:16971387; PubMed:18617530; PubMed:22036712; PubMed:23922729; PubMed:14722920). Has been shown to dephosphorylate MAPT (By similarity). Forms a complex with NHLRC1/malin and HSP70; which suppresses the cellular toxicity of misfolded proteins by promoting their degradation through the ubiquitin-proteasome system (UPS). Acts as a scaffold protein to facilitate PPP1R3C/PTG ubiquitination by NHLRC1/malin (PubMed:23922729). Also promotes proteasome-independent protein degradation through the macroautophagy pathway (PubMed:20453062).
- Gendetails:
- EPM2A glucan phosphatase; laforin
- Host:
- Rabbit
- Immunogen:
- Recombinant Human Laforin protein (244-331AA)
- Isotyp:
- IgG
- Proteindetails:
- Laforin
- Aufreinigung:
- Affinity Purified
- Versandbedingungen:
- Blue Ice
- Lagerbedingungen:
- -20Â[o]C or -80Â[o]C
- Hersteller:
- Aviva Systems Biology
- Typ:
- Antibodies: Polyclonal Antibody
- Datenblatt des Herstellers:html_datasheet.php