EXOSC3 Antibody
Produktgrößen
50ug
£305,00
OACA06417-50UG
100ug
£463,00
OACA06417-100UG
Über dieses Produkt
- SKU:
- OACA06417
- Zusätzliche Namen:
- bA3J10.7;CGI-102;exosome complex component RRP40;exosome complex exonuclease RRP40;Exosome component 3;hRrp-40;p10;PCH1B;ribosomal RNA-processing protein 40;RRP40;Rrp40p.
- Klonalität:
- Polyclonal
- Konjugat:
- Unconjugated
- Weitere Details:
- Non-catalytic component of the RNA exosome complex which has 3'->5' exoribonuclease activity and participates in a multitude of cellular RNA processing and degradation events. In the nucleus; the RNA exosome complex is involved in proper maturation of stable RNA species such as rRNA; snRNA and snoRNA; in the elimination of RNA processing by-products and non-coding 'pervasive' transcripts; such as antisense RNA species and promoter-upstream transcripts (PROMPTs); and of mRNAs with processing defects; thereby limiting or excluding their export to the cytoplasm. The RNA exosome may be involved in Ig class switch recombination (CSR) and/or Ig variable region somatic hypermutation (SHM) by targeting AICDA deamination activity to transcribed dsDNA substrates. In the cytoplasm; the RNA exosome complex is involved in general mRNA turnover and specifically degrades inherently unstable mRNAs containing AU-rich elements (AREs) within their 3' untranslated regions; and in RNA surveillance pathways; preventing translation of aberrant mRNAs. It seems to be involved in degradation of histone mRNA. The catalytic inactive RNA exosome core complex of 9 subunits (Exo-9) is proposed to play a pivotal role in the binding and presentation of RNA for ribonucleolysis; and to serve as a scaffold for the association with catalytic subunits and accessory proteins or complexes. EXOSC3 as peripheral part of the Exo-9 complex stabilizes the hexameric ring of RNase PH-domain subunits through contacts with EXOSC9 and EXOSC5.
- Gendetails:
- exosome component 3
- Host:
- Rabbit
- Immunogen:
- Recombinant Human Exosome complex component RRP40 protein (2-275AA)
- Isotyp:
- IgG
- Proteindetails:
- Exosome complex component RRP40
- Reinheit:
- >95%
- Aufreinigung:
- Protein G Purified
- Versandbedingungen:
- Blue Ice
- Lagerbedingungen:
- -20Â[o]C or -80Â[o]C
- Hersteller:
- Aviva Systems Biology
- Typ:
- Antibodies: Polyclonal Antibody
- Datenblatt des Herstellers:html_datasheet.php