CIART Antibody
Produktgrößen
50ug
£305,00
OACA05770-50UG
100ug
£463,00
OACA05770-100UG
Über dieses Produkt
- SKU:
- OACA05770
- Zusätzliche Namen:
- C1orf51;chIP-derived repressor of network oscillator;CHRONO;circadian-associated transcriptional repressor;computationally highlighted repressor of the network oscillator;GM129.
- Klonalität:
- Polyclonal
- Konjugat:
- Unconjugated
- Konzentration:
- Varies by lot. See vial for concentration.
- Weitere Details:
- Transcriptional repressor which forms a negative regulatory component of the circadian clock and acts independently of the circadian transcriptional repressors: CRY1; CRY2 and BHLHE41. In a histone deacetylase-dependent manner represses the transcriptional activator activity of the CLOCK-ARNTL/BMAL1 heterodimer. Abrogates the interaction of ARNTL/BMAL1 with the transcriptional coactivator CREBBP and can repress the histone acetyl-transferase activity of the CLOCK-ARNTL/BMAL1 heterodimer; reducing histone acetylation of its target genes. Rhythmically binds the E-box elements (5'-CACGTG-3') on circadian gene promoters and its occupancy shows circadian oscillation antiphasic to ARNTL/BMAL1. Interacts with the glucocorticoid receptor (NR3C1) and contributes to the repressive function in the glucocorticoid response (By similarity).
- Gendetails:
- circadian associated repressor of transcription
- Host:
- Rabbit
- Immunogen:
- Recombinant Human Circadian-associated transcriptional repressor protein (1-385AA)
- Isotyp:
- IgG
- Proteindetails:
- Circadian-associated transcriptional repressor
- Reinheit:
- > 95%
- Aufreinigung:
- Protein G Purified
- Versandbedingungen:
- Blue Ice
- Lagerbedingungen:
- -20Â[o]C or -80Â[o]C
- Hersteller:
- Aviva Systems Biology
- Typ:
- Antibodies: Polyclonal Antibody
- Datenblatt des Herstellers:html_datasheet.php