ELAVL1 Antibody
Produktgrößen
50ug
£305,00
OACA04744-50UG
100ug
£463,00
OACA04744-100UG
Über dieses Produkt
- SKU:
- OACA04744
- Zusätzliche Namen:
- ELAV (embryonic lethal; abnormal vision; Drosophila)-like 1 (Hu antigen R);ELAV1;ELAV-like protein 1;embryonic lethal; abnormal vision; drosophila; homolog-like 1;Hu antigen R;Hua;hu-antigen R;HUR;MelG.
- Klonalität:
- Polyclonal
- Konjugat:
- Unconjugated
- Weitere Details:
- RNA-binding protein that binds to the 3'-UTR region of mRNAs and increases their stability (PubMed:14517288; PubMed:18285462). Involved in embryonic stem cells (ESCs) differentiation: preferentially binds mRNAs that are not methylated by N6-methyladenosine (m6A); stabilizing them; promoting ESCs differentiation (By similarity). Binds to poly-U elements and AU-rich elements (AREs) in the 3'-UTR of target mRNAs (PubMed:8626503; PubMed:17632515; PubMed:18285462; PubMed:23519412). Binds avidly to the AU-rich element in FOS and IL3/interleukin-3 mRNAs. In the case of the FOS AU-rich element; binds to a core element of 27 nucleotides that contain AUUUA; AUUUUA; and AUUUUUA motifs. Binds preferentially to the 5'-UUUU[AG]UUU-3' motif in vitro (PubMed:8626503). With ZNF385A; binds the 3'-UTR of p53/TP53 mRNA to control their nuclear export induced by CDKN2A. Hence; may regulate p53/TP53 expression and mediate in part the CDKN2A anti-proliferative activity. May also bind with ZNF385A the CCNB1 mRNA (By similarity).
- Gendetails:
- ELAV like RNA binding protein 1
- Host:
- Rabbit
- Immunogen:
- Recombinant Human ELAV-like protein 1 protein (2-326AA)
- Isotyp:
- IgG
- Proteindetails:
- ELAV-like protein 1
- Aufreinigung:
- Protein G Purified
- Versandbedingungen:
- Blue Ice
- Lagerbedingungen:
- -20Â[o]C or -80Â[o]C
- Hersteller:
- Aviva Systems Biology
- Typ:
- Antibodies: Polyclonal Antibody
- Datenblatt des Herstellers:html_datasheet.php