CSNK2A2 Antibody
Produktgrößen
50ug
£305,00
OACA04648-50UG
100ug
£463,00
OACA04648-100UG
Über dieses Produkt
- SKU:
- OACA04648
- Zusätzliche Namen:
- casein kinase 2 alpha';casein kinase 2; alpha prime polypeptide;casein kinase II subunit alpha';CK II alpha';CK2A2;CK2alpha';CSNK2A1.
- Klonalität:
- Polyclonal
- Konjugat:
- Unconjugated
- Weitere Details:
- Catalytic subunit of a constitutively active serine/threonine-protein kinase complex that phosphorylates a large number of substrates containing acidic residues C-terminal to the phosphorylated serine or threonine. Regulates numerous cellular processes; such as cell cycle progression; apoptosis and transcription; as well as viral infection. May act as a regulatory node which integrates and coordinates numerous signals leading to an appropriate cellular response. During mitosis; functions as a component of the p53/TP53-dependent spindle assembly checkpoint (SAC) that maintains cyclin-B-CDK1 activity and G2 arrest in response to spindle damage. Also required for p53/TP53-mediated apoptosis; phosphorylating 'Ser-392' of p53/TP53 following UV irradiation. Can also negatively regulate apoptosis. Phosphorylates the caspases CASP9 and CASP2 and the apoptotic regulator NOL3. Phosphorylation protects CASP9 from cleavage and activation by CASP8; and inhibits the dimerization of CASP2 and activation of CASP8. Regulates transcription by direct phosphorylation of RNA polymerases I; II; III and IV. Also phosphorylates and regulates numerous transcription factors including NF-kappa-B; STAT1; CREB1; IRF1; IRF2; ATF1; SRF; MAX; JUN; FOS; MYC and MYB. Phosphorylates Hsp90 and its co-chaperones FKBP4 and CDC37; which is essential for chaperone function. Regulates Wnt signaling by phosphorylating CTNNB1 and the transcription factor LEF1. Acts as an ectokinase that phosphorylates several extracellular proteins. During viral infection; phosphorylates various proteins involved in the viral life cycles of EBV; HSV; HBV; HCV; HIV; CMV and HPV.
- Gendetails:
- casein kinase 2 alpha 2
- Host:
- Rabbit
- Immunogen:
- Recombinant Human Casein kinase II subunit alpha\\\' protein (8-350AA)
- Isotyp:
- IgG
- Proteindetails:
- Casein kinase II subunit alpha'
- Aufreinigung:
- Protein G Purified
- Versandbedingungen:
- Blue Ice
- Lagerbedingungen:
- -20Â[o]C or -80Â[o]C
- Hersteller:
- Aviva Systems Biology
- Typ:
- Antibodies: Polyclonal Antibody
- Datenblatt des Herstellers:html_datasheet.php