GSDMD Antibody
Produktgrößen
50ug
£305,00
OACA03071-50UG
100ug
£463,00
OACA03071-100UG
Über dieses Produkt
- SKU:
- OACA03071
- Zusätzliche Namen:
- DF5L;DFNA5L;FKSG10;gasdermin domain containing 1;gasdermin domain-containing protein 1;gasdermin-D;GSDMDC1.
- Klonalität:
- Polyclonal
- Konjugat:
- Unconjugated
- Konzentration:
- Varies by lot. See vial for exact concentration.
- Weitere Details:
- Gasdermin-D; N-terminal: Promotes pyroptosis in response to microbial infection and danger signals. Produced by the cleavage of gasdermin-D by inflammatory caspases CASP1 or CASP4 in response to canonical; as well as non-canonical (such as cytosolic LPS) inflammasome activators (PubMed:26375003; PubMed:26375259; PubMed:27418190). After cleavage; moves to the plasma membrane where it strongly binds to inner leaflet lipids; including monophosphorylated phosphatidylinositols; such as phosphatidylinositol 4-phosphate; bisphosphorylated phosphatidylinositols; such as phosphatidylinositol (4;5)-bisphosphate; as well as phosphatidylinositol (3;4;5)-bisphosphate; and more weakly to phosphatidic acid and phosphatidylserine (PubMed:27281216). Homooligomerizes within the membrane and forms pores of 10 - 15 nanometers (nm) of inner diameter; possibly allowing the release of mature IL1B and triggering pyroptosis (PubMed:27418190; PubMed:27281216). Exhibits bactericidal activity. Gasdermin-D; N-terminal released from pyroptotic cells into the extracellular milieu rapidly binds to and kills both Gram-negative and Gram-positive bacteria; without harming neighboring mammalian cells; as it does not disrupt the plasma membrane from the outside due to lipid-binding specificity (PubMed:27281216). Under cell culture conditions; also active against intracellular bacteria; such as Listeria monocytogenes (By similarity). Strongly binds to bacterial and mitochondrial lipids; including cardiolipin. Does not bind to unphosphorylated phosphatidylinositol; phosphatidylethanolamine nor phosphatidylcholine (PubMed:27281216).
- Gendetails:
- gasdermin D
- Host:
- Rabbit
- Immunogen:
- Recombinant Human Gasdermin-D protein (1-256AA)
- Isotyp:
- IgG
- Proteindetails:
- Gasdermin-D
- Reinheit:
- >95%
- Aufreinigung:
- Protein G Purified
- Versandbedingungen:
- Blue Ice
- Lagerbedingungen:
- -20Â[o]C or -80Â[o]C
- Hersteller:
- Aviva Systems Biology
- Typ:
- Antibodies: Polyclonal Antibody
- Datenblatt des Herstellers:html_datasheet.php