GPR183 Antibody
Produktgrößen
50ug
£305,00
OACA03061-50UG
100ug
£463,00
OACA03061-100UG
Über dieses Produkt
- SKU:
- OACA03061
- Zusätzliche Namen:
- EBI2;EBV-induced G-protein coupled receptor 2;Epstein-Barr virus induced gene 2 (lymphocyte-specific G protein-coupled receptor);epstein-Barr virus-induced G-protein coupled receptor 2;G-protein coupled receptor 183;hEBI2.
- Klonalität:
- Polyclonal
- Konjugat:
- Unconjugated
- Weitere Details:
- G-protein coupled receptor expressed in lymphocytes that acts as a chemotactic receptor for B-cells; T-cells; splenic dendritic cells; monocytes/macrophages and astrocytes (By similarity). Receptor for oxysterol 7-alpha;25-dihydroxycholesterol (7-alpha;25-OHC) and other related oxysterols (PubMed:21796212; PubMed:22875855; PubMed:22930711). Mediates cell positioning and movement of a number of cells by binding the 7-alpha;25-OHC ligand that forms a chemotactic gradient (By similarity). Binding of 7-alpha;25-OHC mediates the correct localization of B-cells during humoral immune responses (By similarity). Guides B-cell movement along the B-cell zone-T-cell zone boundary and later to interfollicular and outer follicular regions (By similarity). Its specific expression during B-cell maturation helps position B-cells appropriately for mounting T-dependent antibody responses (By similarity). Collaborates with CXCR5 to mediate B-cell migration; probably by forming a heterodimer with CXCR5 that affects the interaction between of CXCL13 and CXCR5 (PubMed:22913878). Also acts as a chemotactic receptor for some T-cells upon binding to 7-alpha;25-OHC ligand (By similarity). Promotes follicular helper T (Tfh) cells differentiation by positioning activated T-cells at the follicle-T-zone interface; promoting contact of newly activated CD4 T-cells with activated dendritic cells and exposing them to Tfh-cell-promoting inducible costimulator (ICOS) ligand (By similarity). Expression in splenic dendritic cells is required for their homeostasis; localization and ability to induce B- and T-cell responses: GPR183 acts as a chemotactic receptor in dendritic cells that mediates the accumulation of CD4(+) dendritic cells in bridging channels (By similarity). Regulates migration of astrocytes and is involved in communication between astrocytes and macrophages (PubMed:25297897). Promotes osteoclast precursor migration to bone surfaces (By similarity). Signals constitutively through G(i)-alpha; but not G(s)-alpha or G(q)-alpha (PubMed:21673108; PubMed:25297897). Signals constitutively also via MAPK1/3 (ERK1/2) (By similarity).
- Gendetails:
- G protein-coupled receptor 183
- Host:
- Rabbit
- Immunogen:
- Recombinant Human G-protein coupled receptor 183 protein (1-31AA)
- Isotyp:
- IgG
- Proteindetails:
- G-protein coupled receptor 183
- Reinheit:
- >95%
- Aufreinigung:
- Protein G Purified
- Versandbedingungen:
- Blue Ice
- Lagerbedingungen:
- -20Â[o]C or -80Â[o]C
- Hersteller:
- Aviva Systems Biology
- Typ:
- Antibodies: Polyclonal Antibody
- Datenblatt des Herstellers:html_datasheet.php